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生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
mouse, human
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable
indirect immunofluorescence: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... SFRP1(6422)
一般描述
SFRP1 (secreted frizzled-related protein 1) is a 35.4 kDa antagonist protein.
The encoded protein by SFRP1 gene has a cysteine-rich domain similar to the WNT-binding site of Frizzled receptors. It belongs to the WNT pathway. This gene is located on human chromosome 8p12–11.1.
The encoded protein by SFRP1 gene has a cysteine-rich domain similar to the WNT-binding site of Frizzled receptors. It belongs to the WNT pathway. This gene is located on human chromosome 8p12–11.1.
The gene SFRP1 (secreted frizzled related protein 1) is mapped to human chromosome 8p22–p12, a region frequently deleted in breast cancer. It is highly expressed in normal breast tissue.
免疫原
Synthetic peptide from human SFRP1.
应用
Anti-SFRP1 antibody has been used in western blot analysis.
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Western Blotting (1 paper)
生化/生理作用
SFRP1 (secreted frizzled-related protein 1) plays a major role in the progression of several malignancies. It also plays a vital role in antagonizing Wnt signaling. Overexpression of SFRP1 is linked with apoptosis.
Secreted Frizzled-related protein 1 (SFRP1) is a secreted inhibitor of Wnt signaling pathway. DNA damage or oxidative stress causes cellular senescence, which leads to the overexpression of sfrp1. This protein induces senescence phenotypes via the inactivation of Wnt signaling and activation of the retinoblastoma (Rb) pathway. Mutations or aberrant methylation in this gene impair the induction of senescence in several cancers, including breast cancer, bladder cancer, and colorectal tumorigenesis.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Influence of secreted frizzled receptor protein 1 (SFRP1) on neoadjuvant chemotherapy in triple negative breast cancer does not rely on WNT signaling
Bernemann C, et al.
Molecular Cancer, 13(1), 174-174 (2014)
Effects of supplementation with nondigestible carbohydrates on fecal calprotectin and on epigenetic regulation of SFRP1 expression in the large-bowel mucosa of healthy individuals
Malcomson FC, et al.
American Journal of Clinical Nutrition, 105(2), 400-410 (2017)
Deletions of chromosome 8p and loss of sFRP1 expression are progression markers of papillary bladder cancer
Stoehr R, et al.
Laboratory Investigation; a Journal of Technical Methods and Pathology, 84(4), 465-465 (2004)
WNT pathway and mammary carcinogenesis: Loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type
Ugolini F, et al.
Oncogene, 20(41), 5810-5810 (2001)
J Veeck et al.
Oncogene, 25(24), 3479-3488 (2006-02-02)
The canonical Wnt signalling pathway plays a key role during embryogenesis and defects in this pathway have been implicated in the pathogenesis of various types of tumours, including breast cancer. The gene for secreted frizzled-related protein 1 (SFRP1) encodes a
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