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安全信息

SAB2702316

Sigma-Aldrich

Monoclonal Anti-CEP152 antibody produced in mouse

clone GT1315, affinity isolated antibody

别名:

MCPH4, MCPH9, SCKL5

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

mouse

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

GT1315, monoclonal

形式

buffered aqueous solution

分子量

189kDa

种属反应性

human

浓度

1mg/mL

技术

western blot: 1:500-1:3000

同位素/亚型

IgG1

UniProt登记号

运输

wet ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... CEP152(22995)

相关类别

一般描述

CEP152 (centrosomal protein 152), a mammalian ortholog of Drosphila asterless is a component of mammalian centrosomes. It is located on human chromosome 15.

免疫原

Recombinant protein encompassing a sequence within the N-terminus region of human CEP152.

应用

Suggested starting dilutions are as follows: WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.

生化/生理作用

This gene encodes a protein that is thought to be involved with centrosome function. Mutations in this gene have been associated with primary microcephaly (MCPH4). Alternative splicing results in multiple transcript variants. [provided by RefSeq]
CEP152 (centrosomal protein 152) plays an important role in cell division and development. It is highly essential for the recruitment of centriole of Plk4 (polo-like kinase 4) and centriole duplication at the time of cell cycle.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

其他说明

Purification: Affinity purified by Protein G

外形

Phosphate-buffered saline, no preservative added.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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WGK

WGK 1

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Primary autosomal recessive microcephaly: homozygosity mapping of MCPH4 to chromosome 15.
Jamieson CR, et al.
American Journal of Human Genetics, 65(5), 1465?1469-1465?1469 (1999)
Mutations in centrosomal protein CEP152 in primary microcephaly families linked to MCPH4.
Guernsey DL, et al.
American Journal of Human Genetics, 87(1), 40-51 (2010)
Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication.
Sonnen KF, et al.
Journal of Cell Science, 126(14), 3223-3233 (2013)

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