SAB2700730
单克隆抗TET1 小鼠抗
clone GT1462, affinity isolated antibody, buffered aqueous solution
别名:
FLJ41442, CXXC6, FLJ10839, TET1
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
GT1462, monoclonal
Application:
ChIP
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
Species reactivity:
human, mouse
Citations:
10
Technique(s):
ChIP: suitable
immunofluorescence: suitable
immunohistochemistry: 1:100-1:1000
immunoprecipitation (IP): suitable
western blot: 500-3000
immunofluorescence: suitable
immunohistochemistry: 1:100-1:1000
immunoprecipitation (IP): suitable
western blot: 500-3000
Uniprot accession no.:
产品名称
单克隆抗TET1 小鼠抗, clone GT1462, affinity isolated antibody, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
GT1462, monoclonal
form
buffered aqueous solution
species reactivity
human, mouse
technique(s)
ChIP: suitable
immunofluorescence: suitable
immunohistochemistry: 1:100-1:1000
immunoprecipitation (IP): suitable
western blot: 500-3000
isotype
IgG2
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... TET1(80312)
Other Notes
仅供体外实验室使用。不可用于人类或动物的任何临床、治疗或诊断用途。不供动物或人类食用。
Physical form
磷酸盐缓冲液，未加保护剂。
Preparation Note
以浓溶液保存。分装并储存在-20ºC或更低温度下。避免反复冻融。
Features and Benefits
完放心地使用我们的抗体。如果抗体在您的申请的研究中不起作用，我们将全额退款或安排替代抗体。了解更多信息。
Application
包含人TET1中心区域内序列的重组蛋白。确切序列是专有的。
建议的起始稀释度如下：ICC/IF：1：100-1：1000，免疫组化石蜡切片：1:100-1:1000, IP：1:100-1:500, WB：1:500-1:3000，ChIP检测：检测依赖性稀释。尚未在其他应用中测试。最佳工作稀释度应由最终用户通过实验确定。
Biochem/physiol Actions
Tet甲基胞嘧啶双加氧酶1（TET1）的作用与5-甲基胞嘧啶（5mC）羟化酶相同。它将5-甲基胞嘧啶转化为5-羟甲基胞嘧啶，这对于成人大脑中活跃的DNA去甲基化至关重要。该蛋白质与结直肠癌的进展有关。
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
Tet甲基胞嘧啶双加氧酶1（TET1）是TET家族的一种蛋白质，包含一个结合锌的CXXC结构域。它在胚胎干细胞中表达。TET1基因位于人类染色体10q21.3。
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Skin Sens. 1
存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Genomic and epigenomic analysis of high-risk prostate cancer reveals changes in hydroxymethylation and TET1
Lien Spans, et al.
Oncotarget (2016)
A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer.
Good CR, et al.
Nucleic Acids Research (2017)
LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)
Ryoichi Ono, et al
Cancer Research, 2002 (2002)
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
Mamta Tahiliani et al.
Science, 324 (2009)
Faiza Noreen et al.
Clinical epigenetics, 11(1), 196-196 (2019-12-18)
Aberrations in DNA methylation are widespread in colon cancer (CC). Understanding origin and progression of DNA methylation aberrations is essential to develop effective preventive and therapeutic strategies. Here, we aimed to dissect CC subtype-specific methylation instability to understand underlying mechanisms
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