biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, human
technique(s)
immunohistochemistry: suitable, western blot: 500-3000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ANGPT2(285)
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General description
The ANGPT2 (angiopoietin 2) gene is mapped to 8p23.1. The encoded protein belongs to the family of angiogenic factors.
Immunogen
Recombinant protein fragment contain a sequence corresponding to a region within amino acids 1 and 515 of Angiopoietin 2 according to NP_001138
Application
Suggested starting dilutions are as follows: IHC-P: 1:100-1:1000, WB: 1:500-1:3000. Not yet tested in other applications. Optimal working dilutions should be determined experimentally by the end user.
Biochem/physiol Actions
The protein encoded by the ANGPT2 (angiopoietin 2) gene is an antagonist of angiopoietin 1 (ANGPT1) and endothelial TEK tyrosine kinase (TIE-2, TEK). The encoded protein disrupts the vascular remodeling ability of ANGPT1 and may induce endothelial cell apoptosis. Three transcript variants encoding three different isoforms have been found for this gene. [provided by RefSeq]Ang-2 influences vascular stability by acting as a competitive antagonist of Ang-1. The agonistic function of Ang-2 is essential for lymphatic vascular formation. Overexpression of ANGPT2 is observed in liver cancer and cirrhosis and it induces cell proliferation. It also serves as an important biomarker for liver cancer. Ang-2 stimulates angiogenesis contributing to pathogenesis and progression of a number of chronic liver diseases.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
1XPBS, 20% Glycerol (pH7). 0.025% ProClin 300 was added as a preservative.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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signalword
Warning
hcodes
Hazard Classifications
Aquatic Chronic 3 - Skin Sens. 1
存储类别
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Duplications and copy number variants of 8p23. 1 are cytogenetically indistinguishable but distinct at the molecular level
Barber JCK, et al.
European Journal of Human Genetics, 13(10), 1131-1131 (2005)
Heart Development and Regeneration, 1(10), 552-552 (2010)
Intrahepatic angiopoietin-2 correlates with chronic hepatitis C progression and is induced in hepatitis C virus replicon systems
Hern
Liver International : Official Journal of the International Association For the Study of the Liver, 37(8), 1148-1156 (2017)
Angiopoietin-2 (Ang-2) is a useful serum tumor marker for liver cancer in the Chinese population
Chen Y, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 478, 18-27 (2018)
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