生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
pig, canine, human
技术
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ZNF703(80139)
一般描述
ZNF703 (zinc finger protein 703) belongs to the NET (Noc/Nlz, Elbow, and Tlp-1) protein family, and the corresponding gene is localized to human chromosome 8p12.
免疫原
Peptide with sequence C-ELDKKDQEPKPSPE, from the internal region of the protein sequence according toNP_079345.1
生化/生理作用
ZNF703 (zinc finger protein 703) is a frequently modified gene in the pan-cancer group. In zebrafish and Drosophila, it plays an essential role in embryonic development. Amplification of this gene leads to loss of cell-cell adhesion, and thus, an increase in proliferation and migration. In patients with head and neck squamous cell carcinomas (HNSCC), the overexpression of this protein is linked with poor overall survival. It functions as an oncogene in luminal B breast cancer and gastric cancer, and in colorectal cancer (CRC) it facilitates tumor proliferation and invasion. In CRC patients, it is linked with poor prognosis.
特点和优势
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外形
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
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WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Hang Yang et al.
Disease markers, 2015, 640263-640263 (2015-06-13)
Data from The Cancer Genome Atlas (TCGA) show that the ZNF703 gene amplifies and overexpresses in head and neck squamous cell carcinomas (HNSCC). However, the clinical relevance of this observation in HNSCC is unclear. The purpose of this study was
ZNF703 promotes tumor cell proliferation and invasion and predicts poor prognosis in patients with colorectal cancer.
Ma F et al
Oncology Reports, 32(3), 1071-1077 (2014)
ZNF703 acts as an oncogene that promotes progression in gastric cancer.
Yang G et al
Oncology Reports, 31(4), 1877-1882 (2014)
High expression of ZNF703 independent of amplification indicates worse prognosis in patients with luminal B breast cancer.
Reynisdottir I et al
Cancer Medicine, 2(4), 437-446 (2013)
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