SAB2501506
Anti-ZCCHC11 (C-terminal) antibody produced in goat
affinity isolated antibody, buffered aqueous solution
别名:
Anti-KIAA0191, Anti-bHLHa22, CCHC domain containing 11, PAP associated domain containing 3, Zinc finger
产品名称
Anti-ZCCHC11 (C-terminal) antibody produced in goat, affinity isolated antibody, buffered aqueous solution
biological source
goat
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
canine, bovine, human, rat, mouse
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... ZCCHC11(23318)
Biochem/physiol Actions
Zinc finger CCHC-type containing 11 (ZCCHC11) has a role in the RNA-binding protein Lin28 blockade of let-7 microRNA biogenesis. It is recruited by Lin28 to pre-let-7 (let-7 precursors), where it catalyzes the addition of an oligo (U)-tail.The protein is crucial for poly (A) tail length maintenance. ZCCHC11 also has a role in regulating the stability of transcripts for interleukin-6 and other cytokines.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
General description
Zinc finger CCHC-type containing 11 (ZCCHC11) is a 3′ terminal uridylyl transferase. It possesses multiple domains and has a molecular weight of about 185kDa. A fragment of the protein contains a TRF4 domain, a nucleotidyl transferase domain (NTD), two PAP-associated domains and three zinc finger domains. The ZCCHC11 gene is localized on human chromosome 1p32.3.
Immunogen
Peptide with sequence RERCPHPPRGNVSE, from the C-terminal region of the protein sequence according to NP_001009881.1; NP_056084.1; NP_001009882.1
Physical form
Supplied at 0.5 mg/mL in 20mM Tris (pH 7.3) and 150mM NaCl with 0.02% sodium azide and 0.5% bovine serum albumin.
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Identification of small molecule inhibitors of Zcchc11 TUTase activity.
Lin S and Gregory RI
RNA Biology, 12(8), 792-800 (2015)
Molecular similarity between myelodysplastic form of chronic
myelomonocytic leukemia and refractory anemia with ring
sideroblasts
myelomonocytic leukemia and refractory anemia with ring
sideroblasts
Veronique Gelsi-Boyer
Haematologica (2012)
Zcchc11-dependent uridylation of microRNA directs cytokine expression.
Jones MR, et.al
Nature Cell Biology, 11(9), 1157-1163 (2009)
Matthew R Jones et al.
Nature cell biology, 11(9), 1157-1163 (2009-08-25)
Mounting an effective host immune response without incurring inflammatory injury requires the precise regulation of cytokine expression. To achieve this, cytokine mRNAs are post-transcriptionally regulated by diverse RNA-binding proteins and microRNAs (miRNAs) targeting their 3' untranslated regions (UTRs). Zcchc11 (zinc-finger
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