Anti-PGC1A antibody produced in goat

Anti-PGC1A antibody produced in goat has been used in Western blotting.

Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) modulates the expression of mitochondrial oxidative phosphorylation (OXPHOS) genes and endogenous antioxidants. Variation in the gene expression leads to Huntington′s disease (HD) and Type 2 diabetes. PGC-1α functions as a ‘molecular switch′ in genetic pathways involved in maintaining glucose homeostasis in liver and muscle, β cell insulin secretion and mitochondrial biogenesis. Addition to this, PGC-1α has a crucial role to play in adaptive thermogenesis, skeletal muscle fiber type switching and heart development. PGC-1α reduces or improves muscle dystrophy by stimulating various molecular pathways; therefore, increase in the concentration and activity of PGC-1 is considered to be a potential method for Duchene muscular dystrophy (DMD) treatment.

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Peroxisome proliferator-activated receptor γ (PPARG) coactivator 1 α (PPARGC1A) encodes the 798 amino acid protein, PGC-1α. It is a multifunctional transcriptional protein, which belongs to the family of transcription co-activators involved in the regulation of cellular energy metabolism. PGC-1α is abundantly expressed in several human tissues that are active in oxidative metabolism, including heart, skeletal muscle, and the fasted liver. The gene encoding this protein is localized on human chromosome 4p15.1-2.

Peptide with sequence C-DGLFDDSEDESDK from the internal region of the protein sequence according to NP_037393.1.

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.