一般描述
Pancreatic polypeptide (PPY) or PP is an endogenous peptide hormone. It is secreted by the PP cells of the Islets of Langerhans, in the pancreas. PPY is part of the neuropeptide Y family of hormones. It is a 36 amino acid proteinand the gene encoding it is localized on human chromosome 17q21.31.
免疫原
Peptide with sequence C-TRPRYGKRHKEDT from the internal region of the protein sequence according to NP_002713.1.
应用
Anti-Pancreatic polypeptide/PPY antibody produced in goat has been used in immunohistochemistry and immunofluorescence.
生化/生理作用
Pancreatic polypeptide (PPY) or PP has glucoregulatory functions. It modulates biliary secretion and food digestion by preventing gastric emptying. PPY binds to the Y4 receptor and has a role in increasing the number of insulin receptors on hepatocytes. The protein has been associated with chronic pancreatitis and pancreatogenic diabetes. PPY also negatively regulates the expression of resistin hormone.
特点和优势
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外形
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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法规信息
常规特殊物品
含少量动物源组分生物产品
Human pancreatic polypeptide in a phospholipid-based micellar formulation.
Banerjee A and Onyuksel H
Pharmaceutical Research, 29(6), 1678-1711 (2012)
Strongly altered receptor binding properties in PP and NPY chimeras are accompanied by changes in structure and membrane binding.
Lerch M, et al.
Biochemistry (2005)
Immunohistochemical analysis of pancreatic islets of platypus (Ornithorhynchus anatinus) and echidna (Tachyglossus aculeatus ssp.)
Chuan He, et al.
Journal of Anatomy (2015)
Chuan He et al.
Journal of anatomy, 226(4), 373-380 (2015-02-17)
Monotremes have undergone remarkable changes to their digestive and metabolic control system; however, the monotreme pancreas remains poorly characterized. Previous work in echidna demonstrated the presence of pancreatic islets, but no information is available for platypus and the fine structure
CXCL14-Like Immunoreactivity Exists in Somatostatin-Containing Cells of Mouse Pancreas
Hirohumi Suzuki, Toshiharu Yamamoto
Acta Histochemica Et Cytochemica (2015)
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