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Merck
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主要文件

安全信息

SAB2500745

Sigma-Aldrich

Anti-PAM/PAL antibody produced in goat

affinity isolated antibody, buffered aqueous solution

别名:

Anti-PAL, Anti-PHM, Anti-Pancreatic peptidylglycine α-amidating monooxygenase, Anti-Peptidyl α-amidating enzyme, Anti-Peptidylglycine α-amidating monooxygenase

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About This Item

MDL编号:
UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

goat

质量水平

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

种属反应性

human

技术

indirect ELISA: suitable
western blot: suitable

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... PAM(5066)

一般描述

Peptidylglycine α-amidating monooxygenase (PAM) is expressed in endocrine cells and neurons. It consists of two enzyme activities- peptidyl-glycine α-hydroxylating monoxygenase (PHM) and peptidyl-α-hydroxyglycine amidating lyase (PAL). The PAM gene is localized on human chromosome 5q21.1.

免疫原

Peptide with sequence C-DQEKEDDGSESEE from the C Terminus of the protein sequence according to NP_000910.2; NP_620121.1; NP_620176.1; NP_620177.1.

生化/生理作用

Peptidylglycine α-amidating monooxygenase (PAM) has a role in the biosynthesis of bioactive peptides. It is involved in C-terminal α-amidation, which influences the activity of regulatory peptides of the respiratory tract.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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象形图

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警示用语:

Warning

危险声明

预防措施声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

10 - Combustible liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

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分析证书(COA)

Lot/Batch Number

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访问文档库

The endocytic pathways of a secretory granule membrane protein in HEK293 cells: PAM and EGF traverse a dynamic multivesicular body network together.
Back N, et al.
European Journal of Cell Biology, 96(5), 407-417 (2017)
Localization of the gene encoding peptidylglycine alpha-amidating monooxygenase (PAM) to human chromosome 5q14-5q21.
Ouafik LH, et al.
Genomics, 18(2), 319-321 (1993)
Peptidylglycine alpha-amidating monooxygenase: a multifunctional protein with catalytic, processing, and routing domains.
Eipper BA, et al.
Protein Science, 2(4), 489-497 (1993)
Distribution of peptidyl-glycine alpha-amidating mono-oxygenase (PAM) enzymes in normal human lung and in lung epithelial tumors.
Saldise L, et al.
The Journal of Histochemistry and Cytochemistry, 44(1), 3-12 (1996)

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