推荐产品
生物来源
goat
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
rat, human, mouse
技术
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GJB2(2706)
一般描述
Gap junction protein β 2 (GJB2) or connexin 26 (CX26) is a gap junction protein which is part of the connexin (Cx) family. It is expressed in epidermal keratinocytes and cochlea. The protein has four a-helical transmembrane domains, two extracellular loops, a cytoplasmic N-terminal domain and a C-terminal domain. The gene encoding GJB2 consists of two exons and is localized on human chromosome 13q12.
免疫原
Peptide with sequence YLLIRYCSGKSKKP from the C Terminus of the protein sequence according to NP_003995.2.
应用
Anti-GJB2/Connexin 26 antibody produced in goat has been used in Western blotting.
生化/生理作用
Gap junction protein β 2 (GJB2) forms hexameric transmembrane channels called connexons, which is vital for gap junction communication. It has a role in the migration of cortical neurons during cortex development. GJB2 is involved in recycling potassium ions which is crucial for the hearing process. Mutations in the gene encoding this protein have been associated with skin disorders and sensorineural hearing loss.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Induction of cell death and gain-of-function properties of connexin26 mutants predict severity of skin disorders and hearing loss.
Press ER
The Journal of Biological Chemistry (2017)
Non-junctional Cx32 mediates anti-apoptotic and pro-tumor effects via epidermal growth factor receptor in human cervical cancer cells
Yifan Zhao
Cell Death & Disease (2017)
Revertant mosaicism repairs skin lesions in a patient with keratitis-ichthyosis-deafness syndrome by second-site mutations in connexin 26.
Gudmundsson S
Human Molecular Genetics, 26(6) (2017)
Rare compound heterozygosity involving dominant and recessive mutations of GJB2 gene in an assortative mating hearing impaired Indian family.
Pavithra A
European Archives of Oto-Rhino-Laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery (2017)
GJB2 Gene Mutations in Syndromic Skin Diseases with Sensorineural Hearing Loss.
Sandra Iossa
Current Genomics (2011)
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
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