Anti-GJB2/Connexin 26 antibody produced in goat

Gap junction protein β 2 (GJB2) or connexin 26 (CX26) is a gap junction protein which is part of the connexin (Cx) family. It is expressed in epidermal keratinocytes and cochlea. The protein has four a-helical transmembrane domains, two extracellular loops, a cytoplasmic N-terminal domain and a C-terminal domain. The gene encoding GJB2 consists of two exons and is localized on human chromosome 13q12.

Peptide with sequence YLLIRYCSGKSKKP from the C Terminus of the protein sequence according to NP_003995.2.

Anti-GJB2/Connexin 26 antibody produced in goat has been used in Western blotting.

Gap junction protein β 2 (GJB2) forms hexameric transmembrane channels called connexons, which is vital for gap junction communication. It has a role in the migration of cortical neurons during cortex development. GJB2 is involved in recycling potassium ions which is crucial for the hearing process. Mutations in the gene encoding this protein have been associated with skin disorders and sensorineural hearing loss.

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Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

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