生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
种属反应性
rat, human, mouse, canine
技术
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... GCNT3(9245)
一般描述
The GCNT3 (glucosaminyl (N-acetyl) transferase 3, mucin type) gene codes for an enzyme synthesizing the core of mucin protein and is mapped to human chromosome 15q22.2. The enzyme is predominantly expressed in stomach and colon.
免疫原
Peptide with sequence C-NKFDPKVDDNALQ from the internal region (near C terminus) of the protein sequence according to NP_004742.1.
生化/生理作用
Gcnt3 (glucosaminyl (N-acetyl) transferase 3, mucin type) is involved in the biosynthesis of core 2, core 4 and blood group I antigen in secreted mucins. Overexpression of GCNT3 gene is observed in human pancreatic cancer and contributes to elevated mucin formation, aggressive tumorigenesis and decreased patient survival. The GCNT3 gene is known to promote cell proliferation and spheroid formation in tumors. Deletion of GCNT3 gene results in loss of core 2 O-glycan in the stomach and colon.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
警示用语:
Warning
危险声明
预防措施声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Core 2 Mucin-Type O-Glycan Is Related to EPEC and EHEC O157:H7 Adherence to Human Colon Carcinoma HT-29 Epithelial Cells.
Digestive Diseases and Sciences, 60(7), 1977?1990-1977?1990 (2015)
Allelic Skewing of DNA Methylation Is Widespread across the Genome.
American Journal of Human Genetics, 86(2), 196-212 (2010)
Keratin 1 Plays a Critical Role in Golgi Localization of Core 2 N-Acetylglucosaminyltransferase M via Interaction with Its Cytoplasmic Tail.
The Journal of Biological Chemistry, 290(10), 6256-6269 (2015)
Molecular Pathways: Mucins and Drug Delivery in Cancer.
Clinical Cancer Research (2017)
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门