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安全信息

SAB2500237

Sigma-Aldrich

Anti-CHRNA4 (AA 29-43) antibody produced in goat

affinity isolated antibody, buffered aqueous solution

别名:

Anti-BFNC, Anti-Cholinergic receptor nicotinic α4, Anti-EBN

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About This Item

UNSPSC代码:
12352203
NACRES:
NA.41

生物来源

goat

偶联物

unconjugated

抗体形式

affinity isolated antibody

抗体产品类型

primary antibodies

克隆

polyclonal

表单

buffered aqueous solution

种属反应性

mouse, human, canine, bovine, rat

技术

indirect ELISA: suitable
western blot: suitable

UniProt登记号

运输

dry ice

储存温度

−20°C

靶向翻译后修饰

unmodified

基因信息

human ... CHRNA4(1137)

一般描述

CHRNA4 (cholinergic receptor nicotinic α4 subunit) encodes the α4 subunit of α4/β2-containing receptors. This gene is ~17 kb long and has six exons. CHRNA4 is located on human chromosome 20q13.2–13.3.

免疫原

Peptide with sequence C-HVETRAHAEERLLKK from the internal region of the protein sequence according to NP_000735.1.

生化/生理作用

CHRNA4 (cholinergic receptor nicotinic α 4 subunit) plays an important role in ND (nicotine dependence). Mutations in CHRNA4 is linked with PIU (problematic internet use). In adult males, polymorphism in CHRNA4 is associated with depression and loneliness.

特点和优势

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

外形

Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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象形图

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警示用语:

Warning

危险声明

预防措施声明

危险分类

Eye Irrit. 2 - Skin Irrit. 2

储存分类代码

12 - Non Combustible Liquids

WGK

WGK 2

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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访问文档库

Association of CHRNA4 polymorphism with depression and loneliness in elderly males.
Tsai S J, et al.
Genes, Brain, and Behavior, 11(2), 230-234 (2012)
The association between the nicotinic acetylcholine receptor ?4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults.
Jeong JE, et al.
PLoS ONE, 12(12), e0188358-e0188358 (2017)
Ethnic-and gender-specific association of the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) with nicotine dependence.
Li M D, et al.
Human Molecular Genetics, 14(9), 1211-1219 (2005)
Association of common polymorphisms in the nicotinic acetylcholine receptor alpha4 subunit gene with an electrophysiological endophenotype in a large population-based sample.
Mobascher A, et al.
PLoS ONE, 11(4), e0152984-e0152984 (2016)

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