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生物来源
goat
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
mouse, human, canine, bovine, rat
技术
indirect ELISA: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... CHRNA4(1137)
一般描述
CHRNA4 (cholinergic receptor nicotinic α4 subunit) encodes the α4 subunit of α4/β2-containing receptors. This gene is ~17 kb long and has six exons. CHRNA4 is located on human chromosome 20q13.2–13.3.
免疫原
Peptide with sequence C-HVETRAHAEERLLKK from the internal region of the protein sequence according to NP_000735.1.
生化/生理作用
CHRNA4 (cholinergic receptor nicotinic α 4 subunit) plays an important role in ND (nicotine dependence). Mutations in CHRNA4 is linked with PIU (problematic internet use). In adult males, polymorphism in CHRNA4 is associated with depression and loneliness.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Warning
危险声明
预防措施声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2
储存分类代码
12 - Non Combustible Liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Association of CHRNA4 polymorphism with depression and loneliness in elderly males.
Tsai S J, et al.
Genes, Brain, and Behavior, 11(2), 230-234 (2012)
The association between the nicotinic acetylcholine receptor ?4 subunit gene (CHRNA4) rs1044396 and Internet gaming disorder in Korean male adults.
Jeong JE, et al.
PLoS ONE, 12(12), e0188358-e0188358 (2017)
Ethnic-and gender-specific association of the nicotinic acetylcholine receptor α4 subunit gene (CHRNA4) with nicotine dependence.
Li M D, et al.
Human Molecular Genetics, 14(9), 1211-1219 (2005)
Association of common polymorphisms in the nicotinic acetylcholine receptor alpha4 subunit gene with an electrophysiological endophenotype in a large population-based sample.
Mobascher A, et al.
PLoS ONE, 11(4), e0152984-e0152984 (2016)
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