推荐产品
生物来源
goat
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human
技术
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: suitable
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... ASPN(54829)
一般描述
Asporin (ASPN) is an extracellular matrix (ECM) macromolecule. It is encoded by the gene mapped to human chromosome 9q22.31. ASPN is a member of small leucine-rich proteoglycan (SLRP) family.
免疫原
Peptide with sequence C-IHENKVKKIQKDT from the internal region of the protein sequence according to NP_060150.3.
生化/生理作用
Asporin (ASPN) plays a vital role in regulation of chondrogenesis and helps to maintain the cartilage matrix. ASPN also facilitates transforming growth factor (TGF)-f-mediated signaling. It stimulates osteoblast collagen mineralization by interacting with collagen and calcium. Mutation in the gene is associated with the development of acetabular dysplasia (AD) and hip osteoarthritis.
特点和优势
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
外形
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
含少量动物源组分生物产品
常规特殊物品
Asporin competes with decorin for collagen binding, binds calcium and promotes osteoblast collagen mineralization.
Kalamajski S, et al.
The Biochemical Journal, 423(1), 53-59 (2009)
The CALM1 core promoter polymorphism is not associated with hip osteoarthritis in a United Kingdom Caucasian population.
Loughlin J, et al.
Osteoarthritis and Cartilage, 14(3), 295-298 (2006)
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