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安全信息

S7147

Sigma-Aldrich

Secretin human

≥97% (HPLC), powder

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About This Item

经验公式（希尔记法）:
C130H220N44O40
CAS号:
108153-74-8
分子量:
3039.41
MDL编号:
MFCD00135670
UNSPSC代码:
51111800
PubChem化学物质编号:
329824578
NACRES:
NA.32

质量水平

200

检测方案

≥97% (HPLC)

形式

powder

UniProt登记号

P09683
P47872

储存温度

−20°C

SMILES字符串

CC(C)C[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc2c[nH]cn2)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](C(C)C)C(N)=O

InChI

1S/C130H220N44O40/c1-60(2)43-81(120(208)173-100(66(13)14)103(134)191)153-95(183)54-149-106(194)77(31-35-92(132)180)159-116(204)84(46-63(7)8)166-118(206)85(47-64(9)10)164-111(199)75(29-23-41-146-129(139)140)155-113(201)79(32-36-93(133)181)160-117(205)83(45-62(5)6)162-110(198)73(27-21-39-144-127(135)136)154-104(192)67(15)152-94(182)53-148-107(195)78(33-37-97(185)186)158-109(197)74(28-22-40-145-128(137)138)156-115(203)82(44-61(3)4)163-112(200)76(30-24-42-147-130(141)142)157-122(210)90(57-176)170-119(207)86(48-65(11)12)165-114(202)80(34-38-98(187)188)161-123(211)91(58-177)171-126(214)102(69(17)179)174-121(209)87(49-70-25-19-18-20-26-70)168-125(213)101(68(16)178)172-96(184)55-150-108(196)88(51-99(189)190)167-124(212)89(56-175)169-105(193)72(131)50-71-52-143-59-151-71/h18-20,25-26,52,59-69,72-91,100-102,175-179H,21-24,27-51,53-58,131H2,1-17H3,(H2,132,180)(H2,133,181)(H2,134,191)(H,143,151)(H,148,195)(H,149,194)(H,150,196)(H,152,182)(H,153,183)(H,154,192)(H,155,201)(H,156,203)(H,157,210)(H,158,197)(H,159,204)(H,160,205)(H,161,211)(H,162,198)(H,163,200)(H,164,199)(H,165,202)(H,166,206)(H,167,212)(H,168,213)(H,169,193)(H,170,207)(H,171,214)(H,172,184)(H,173,208)(H,174,209)(H,185,186)(H,187,188)(H,189,190)(H4,135,136,144)(H4,137,138,145)(H4,139,140,146)(H4,141,142,147)/t67-,68+,69+,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,86-,87-,88-,89-,90-,91-,100-,101-,102-/m0/s1

InChI key

OWMZNFCDEHGFEP-NFBCVYDUSA-N

基因信息

human ... SCT(6343) , SCTR(6344)

Amino Acid Sequence

His-Ser-Asp-Gly-Thr-Phe-Thr-Ser-Glu-Leu-Ser-Arg-Leu-Arg-Glu-Gly-Ala-Arg-Leu-Gln-Arg-Leu-Leu-Gln-Gly-Leu-Val-NH2

一般描述

Secretin is a gastrointestinal hormone and a neuropeptide. It is synthesized from a precursor protein and shares sequence homology with other secretin family proteins like glucagon and vasoactive intestinal peptide (VIP).

应用

Secretin human has been used:
  • in the radioimmunoassay with oxyntomodulin
  • to test its effect on the enlargement and swelling of human endoderm stem cells (hEnSCs) derived cyst
  • to stimulate human induced pluripotent stem cells (iPSC)-derived biliary cells in cyclic adenosine monophosphate (cAMP) assays to test its effect on cAMP production

生化/生理作用

Secretin regulates the secretion of gastric acid and pancreatic bicarbonates. It serves as an antidiuretic hormone in the neurohypophysial-renal axis and participates in osmoregulation. Secretin mediates its function through the G-protein coupled secretin receptors. It regulates the pH of the duodenal by modulating gastric acid secretion.
Stimulates secretion of carbonate-rich pancreatic fluid; relaxes smooth muscle

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

监管及禁止进口产品

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Syeda Afroze et al.
Annals of translational medicine, 1(3), 29-29 (2014-10-22)
Secretin is secreted by S cells in the small intestine and affects the function of a number of organ systems. Secretin receptors (SR) are expressed in the basolateral domain of several cell types. In addition to regulating the secretion of
S ThanThan et al.
Domestic animal endocrinology, 39(3), 163-170 (2010-08-14)
Ghrelin, the natural ligand of the growth hormone secretagogue receptor (GHS-R1a), has been shown to stimulate growth hormone (GH) secretion. Regulation of ghrelin secretion in ruminants is not well studied. We investigated the effects of oxyntomodulin (OXM) and secretin on
Vien H Y Lee et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 24(12), 5024-5032 (2010-08-27)
Fluid balance is critical to life and hence is tightly controlled in the body. Angiotensin II (ANGII), one of the most important components of this regulatory system, is recognized as a dipsogenic hormone that stimulates vasopressin (VP) expression and release.
Lipeng Tian et al.
Journal of pediatric gastroenterology and nutrition, 68(1), 56-63 (2018-10-26)
Biliary atresia (BA) is the most common cause of pediatric end-stage liver disease and the etiology is poorly understood. There is no effective therapy for BA partly due to lack of human BA models. Towards developing in vitro human models
Sisi Feng et al.
Cell reports, 33(10), 108455-108455 (2020-12-10)
The ever-increasing therapeutic and pharmaceutical demand for liver cells calls for systems that enable mass production of hepatic cells. Here we describe a large-scale suspension system that uses human endoderm stem cells (hEnSCs) as precursors to generate functional and transplantable

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