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描述
non-ionic
质量水平
分子量
430.63 g/mol
浓度
45-55% (GC)
SMILES字符串
CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O
InChI
1S/C24H46O6/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-22(27)29-19-21(26)24-23(28)20(25)18-30-24/h20-21,23-26,28H,2-19H2,1H3/t20-,21?,23+,24+/m0/s1
InChI key
HVUMOYIDDBPOLL-XGKPLOKHSA-N
一般描述
Span® 60 是一种山梨醇单酯，用作非离子型洗涤剂。
应用
Span® 60曾在一项研究中用于评估阿霉素在囊泡中的包封，作为肿瘤靶向的一种途径。 也有研究用非离子型表面活性剂作为造影剂用于诊断超声。
其他说明
脂肪酸组成：硬脂酸 (C18:0) 约 50%；主要平衡棕榈酸 (C16:0)。
法律信息
Span is a registered trademark of Croda International PLC
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Preparation and properties of vesicles (niosomes) of sorbitan monoesters ([TM="Span"] 20, 40, 60 and 80) and a sorbitan triester ([TM="Span"] 85).
Yoshioka, T., et al.
International Journal of Pharmaceutics, 105, 1-1 (1994)
I F Uchegbu et al.
Pharmaceutical research, 12(7), 1019-1024 (1995-07-01)
Encapsulation of doxorubicin in niosomes was sought as a route to tumour targeting and improved tumoricidal through the alteration of doxorubicin pharmacokinetics and metabolism. Doxorubicin niosomes (10 mg kg-1 doxorubicin) prepared from sorbitan monostearate (Span 60), cholesterol and choleth-24 (a
Surfactant-stabilized microbubbles as ultrasound contrast agents: stability study of [TM="Span"] 60 and Tween 80 mixtures using a Langmuir trough
Singhal, S., et al.
Langmuir, 9, 2426-2426 (1993)
Karimunnisa Sameer Shaikh et al.
Drug development and industrial pharmacy, 36(8), 946-953 (2010-03-04)
Niosomal delivery can prove an alternative to improve the poor skin penetration and residence of the topical antifungal drugs that account for the long treatment regimes in cutaneous mycosis. To investigate niosomes as carriers for dermal delivery of ciclopirox olamine
F Podczeck et al.
International journal of pharmaceutics, 361(1-2), 33-40 (2008-06-24)
The aim of the study was to investigate the possibility of incorporating non-ionic surfactants into pellets produced from microcrystalline cellulose by the process of extrusion/spheronization and the properties of the pellets. A hydrophilic surfactant, polysorbate 60 (PS 60), and two
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