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S4317

SB 431542 水合物

Name: SB 431542 水合物
Brand: SIGMA

≥98% (HPLC), powder, inhibits activation of SMAD proteins

别名:

4-(5-苯并[1,3]二唑-5-基-4-吡啶-2-基-1H-咪唑-2-基)-苯甲酰胺水合物, 4-[4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯甲酰胺水合物, 4-[4-(3,4-亚甲二氧基苯基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯甲酰胺水合物

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About This Item

经验公式（希尔记法）:

C₂₂H₁₆N₄O₃ · xH₂O

CAS号:

301836-41-9

分子量:

384.39 (anhydrous basis)

MDL编号:

MFCD11045982

UNSPSC代码:

51111800

PubChem化学物质编号:

24724609

NACRES:

NA.77

product name

SB 431542 水合物, ≥98% (HPLC), powder

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

溶解性

DMSO: soluble 10 mg/mL
H₂O: insoluble

创始人

GlaxoSmithKline

储存温度

−20°C

SMILES字符串

O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5

InChI

1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2

InChI key

WQUIJVKNPYBZOF-UHFFFAOYSA-N

应用

SB-431542被用于研究结直肠肿瘤细胞中血小板衍生生长因子受体B表达与TGF-β途径激活的相关性。它被用于研究TGF-β信号传导在调节细胞外基质和成肌细胞分化中的作用。

生化/生理作用

SB-431542可抑制TGF-β介导的SMAD蛋白活化、胶原和纤连蛋白表达、细胞增殖和细胞运动。它不抑制因血清或应激而激活的激酶，如ERK、p38或JNK。

转化生长因子-β超家族I型激活素受体样激酶（ALK）受体的有效和选择性抑制剂。

特点和优势

该化合物由 GlaxoSmithKline开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单，请单击此处。

法律信息

根据GlaxoSmithKline协议出售，用于研究目的

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

分析证书(COA)

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A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.

Isogaya K, Koinuma D, Tsutsumi S, et al.

Cell Research, 24(8), 994-1008 (2014)

The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-beta signaling.

Douglas S Micalizzi et al.

The Journal of clinical investigation, 119(9), 2678-2690 (2009-09-04)

Inappropriate activation of developmental pathways is a well-recognized tumor-promoting mechanism. Here we show that overexpression of the homeoprotein Six1, normally a developmentally restricted transcriptional regulator, increases TGF-beta signaling in human breast cancer cells and induces an epithelial-mesenchymal transition (EMT) that

PDGFRB promotes liver metastasis formation of mesenchymal-like colorectal tumor cells.

Ernst J A Steller et al.

Neoplasia (New York, N.Y.), 15(2), 204-217 (2013-02-27)

In epithelial tumors, the platelet-derived growth factor receptor B (PDGFRB) is mainly expressed by stromal cells of mesenchymal origin. Tumor cells may also acquire PDGFRB expression following epithelial-to-mesenchymal transition (EMT), which occurs during metastasis formation. Little is known about PDGFRB

ALK3-SMAD1/5 Signaling Mediates the BMP2-Induced Decrease in PGE2 Production in Human Endometrial Stromal Cells and Decidual Stromal Cells.

Yu Zhang et al.

Frontiers in cell and developmental biology, 8, 573028-573028 (2020-10-13)

BMP2 is a critical factor that is involved in the processes of embryo implantation and uterine decidualization. The expression of cyclooxygenase (COX) and subsequent prostaglandin E2 (PGE2) production are critical for successful pregnancy. However, it is not clear whether BMP2

Bone Metastasis Phenotype and Growth Undergo Regulation by Micro-Environment Stimuli: Efficacy of Early Therapy with HGF or TGFβ1-Type I Receptor Blockade.

Paola Bendinelli et al.

International journal of molecular sciences, 20(10) (2019-05-28)

Hepatocyte growth factor (HGF) and transforming growth factor β1 (TGFβ1) are biological stimuli of the micro-environment which affect bone metastasis phenotype through transcription factors, but their influence on the growth is scarcely known. In a xenograft model prepared with 1833

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