跳转至内容

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
所有图片(3)

主要文件

查看所有文档

S4317

Sigma-Aldrich

SB 431542 水合物

≥98% (HPLC), powder, inhibits activation of SMAD proteins

别名:

4-(5-苯并[1,3]二唑-5-基-4-吡啶-2-基-1H-咪唑-2-基)-苯甲酰胺 水合物, 4-[4-(1,3-苯并二唑-5-基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯甲酰胺 水合物, 4-[4-(3,4-亚甲二氧基苯基)-5-(2-吡啶基)-1H-咪唑-2-基]-苯甲酰胺 水合物

登录查看公司和协议定价

选择尺寸

100 μL
¥5,074.24

¥5,074.24

国内现货，预计发货时间2025年4月14日详情

获取大包装报价
所有图片(3)

选择尺寸

变更视图
100 μL
¥5,074.24

About This Item

经验公式（希尔记法）:
C22H16N4O3 · xH2O
CAS号:
301836-41-9
分子量:
384.39 (anhydrous basis)
MDL编号:
MFCD11045982
UNSPSC代码:
51111800
PubChem化学物质编号:
24724609
NACRES:
NA.77

¥5,074.24

国内现货，预计发货时间2025年4月14日详情

获取大包装报价

产品名称

SB 431542 水合物, ≥98% (HPLC), powder

方案

≥98% (HPLC)

表单

powder

溶解性

DMSO: soluble 10 mg/mL
H2O: insoluble

创始人

GlaxoSmithKline

储存温度

−20°C

SMILES字符串

O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5

InChI

1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2

InChI key

WQUIJVKNPYBZOF-UHFFFAOYSA-N

比较类似商品

查看完整比较结果

显示差异

1 of 4

此商品
B9285D5412I7125
5-溴-2′-脱氧尿苷 ≥99% (HPLC)

B5002

5-溴-2′-脱氧尿苷

5-溴-2′-脱氧尿苷 BioUltra, ≥99%

B9285

5-溴-2′-脱氧尿苷

2′-脱氧尿苷 ≥98.5%

D5412

2′-脱氧尿苷

5-碘-2′-脱氧尿苷 ≥99% (HPLC)

I7125

5-碘-2′-脱氧尿苷

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

assay

≥99% (HPLC)

assay

≥99%

assay

≥98.5%

assay

≥99% (HPLC)

form

powder

form

powder

form

powder

form

powder or crystals

storage temp.

−20°C

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

solubility

DMSO: 50 mg/mL, clear, colorless to very faintly yellow

solubility

NH4OH: 0.1 M at 20 °C, clear, colorless

solubility

water: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

solubility

1 N NH4OH: 50 mg/mL, clear to very slightly hazy, colorless to light yellow

应用

SB-431542被用于研究结直肠肿瘤细胞中血小板衍生生长因子受体B表达与TGF-β途径激活的相关性。[1]它被用于研究TGF-β信号传导在调节细胞外基质[2] 和成肌细胞分化中的作用。[3]

生化/生理作用

SB-431542可抑制TGF-β介导的SMAD蛋白活化、胶原和纤连蛋白表达、细胞增殖和细胞运动。[4][5][6]它不抑制因血清或应激而激活的激酶，如ERK、p38或JNK。[5]
转化生长因子-β超家族I型激活素受体样激酶（ALK）受体的有效和选择性抑制剂。

特点和优势

该化合物由 GlaxoSmithKline开发。想要浏览其他由制药公司开发的化合物以及已批准物/候选药物清单， 请单击此处。

法律信息

根据Glaxo­Smith­Kline协议出售，用于研究目的

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000441946
    0000441946
    0000430421
    0000430421
    0000429567

    没有发现合适的版本？

    如果您需要特殊版本，可通过批号或批次号查找具体证书。

    搜索COA

    已有该产品？

    在文件库中查找您最近购买产品的文档。

    访问文档库

    A Smad3 and TTF-1/NKX2-1 complex regulates Smad4-independent gene expression.
    Isogaya K, Koinuma D, Tsutsumi S, et al.
    Cell Research, 24(8), 994-1008 (2014)
    N J Laping et al.
    Molecular pharmacology, 62(1), 58-64 (2002-06-18)
    Transforming growth factor beta1 (TGF-beta1) is a potent fibrotic factor responsible for the synthesis of extracellular matrix. TGF-beta1 acts through the TGF-beta type I and type II receptors to activate intracellular mediators, such as Smad proteins, the p38 mitogen-activated protein
    Ernst J A Steller et al.
    Neoplasia (New York, N.Y.), 15(2), 204-217 (2013-02-27)
    In epithelial tumors, the platelet-derived growth factor receptor B (PDGFRB) is mainly expressed by stromal cells of mesenchymal origin. Tumor cells may also acquire PDGFRB expression following epithelial-to-mesenchymal transition (EMT), which occurs during metastasis formation. Little is known about PDGFRB
    Douglas S Micalizzi et al.
    The Journal of clinical investigation, 119(9), 2678-2690 (2009-09-04)
    Inappropriate activation of developmental pathways is a well-recognized tumor-promoting mechanism. Here we show that overexpression of the homeoprotein Six1, normally a developmentally restricted transcriptional regulator, increases TGF-beta signaling in human breast cancer cells and induces an epithelial-mesenchymal transition (EMT) that
    Paola Bendinelli et al.
    International journal of molecular sciences, 20(10) (2019-05-28)
    Hepatocyte growth factor (HGF) and transforming growth factor β1 (TGFβ1) are biological stimuli of the micro-environment which affect bone metastasis phenotype through transcription factors, but their influence on the growth is scarcely known. In a xenograft model prepared with 1833
    查看所有相关文献

    实验方案

    Neural Stem Cell Culture Protocols

    Step-by-step culture protocols for neural stem cell culture including NSC isolation, expansion, differentiation and characterization.

    我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

    联系客户支持