推荐产品
生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
种属反应性
human
技术
immunohistochemistry: 5-10 μg/mL using human brain neurons
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HTR4(3360)
mouse ... Htr4(15562)
rat ... Htr4(25324)
一般描述
Serotonin 5-HT4 receptor (HTR4) gene with five exons spanning ∼1.3 Mb, is mapped to human chromosome 5q32. The protein is majorly found in the central nervous system, mainly in limbic structures. HTR4 protein is also expressed in lower levels in various types of tissues including esophagus, ileum, colon, adrenocortical cells, urinary bladder, and heart. HTR4 belongs to the G protein-coupled receptor (GPCR) superfamily. Anti-Serotonin 5-HT4 receptor specifically recognizes human serotonin 5-HT4 receptor.
特异性
Anti-Serotonin 5-HT4 Receptor specifically recognizeshuman serotonin 5-HT4 receptor.
免疫原
synthetic peptide corresponding to the third cytoplasmic loop of human serotonin 5-HT4 receptor, conjugated to KLH. The immunizing peptide has 100% homology with the rat gene and 94% homology with the mouse gene.
生化/生理作用
Serotonin 5-HT4 receptor (HTR4) plays a vital role in psychomotor function and regulation of dopamine secretion. In the central nervous system, HTR4 aids in learning and memory, depression, anxiety, and feeding behavior. HTR4 gene polymorphism leads to the development of asthma, attention-deficit/hyperactivity disorder (ADHD), mood disorders, and schizophrenia.
外形
Solution in phosphate buffered saline containing 0.1% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
未找到合适的产品？
试试我们的产品选型工具.
储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
T Ohtsuki et al.
Molecular psychiatry, 7(9), 954-961 (2002-10-26)
Possible irregularities in serotonergic neurotransmission have been suggested as causes of a variety of neuropsychiatric diseases. We performed mutation and association analyses of the HTR4 gene, on 5q32, encoding the serotonin 4 receptor in mood disorders and schizophrenia. Mutation analysis
Tae-Hoon Kim et al.
Respirology (Carlton, Vic.), 16(4), 630-638 (2011-03-09)
The neurotransmitter, 5-hydroxytryptamine, acts as an immunomodulator by stimulating the release of inflammatory cytokines and regulating the function of dendritic cells and monocytes. The 5-hydroxytryptamine receptor 4 (HTR4) gene is located in a region previously linked to an increased risk
Jun Li et al.
Neuroscience letters, 401(1-2), 6-9 (2006-03-28)
Attention-deficit/hyperactivity disorder (ADHD) is an important public health problem. Although serotonin is believed to be an important neurotransmitter in the etiology of this disorder, it remains unclear which specific 5-HT receptors are involved in regulating the symptoms of ADHD. Previous
Emily Hodge et al.
Respiratory research, 14, 77-77 (2013-07-31)
Meta-analyses of genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) spanning the 5-hydroxytryptamine receptor 4 (5-HT₄R) gene (HTR4) associated with lung function. The aims of this study were to i) investigate the expression profile of HTR4 in adult
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门