所有图片(1)
别名:
6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole
经验公式（希尔记法）:
C16H12N3FS
推荐产品
质量水平
检测方案
≥98% (HPLC)
形式
solid
储存条件
protect from light
颜色
off-white
mp
189-190 °C (lit.)
溶解性
DMSO: soluble >10 mg/mL
储存温度
2-8°C
SMILES字符串
Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4
InChI
1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
InChI key
YOELZIQOLWZLQC-UHFFFAOYSA-N
基因信息
human ... IL1B(3553) , TNF(7124)
rat ... Alox5(25290)
生化/生理作用
p38 MAP kinase inhibitor.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
M Pouliot et al.
Journal of immunology (Baltimore, Md. : 1950), 158(10), 4930-4937 (1997-05-15)
Prostaglandin endoperoxide synthase (PGHS; cyclooxygenase), the rate-limiting enzyme in the conversion of arachidonic acid to prostanoids, has two isoforms. PGHS-1 is constitutively expressed and involved in homeostasis, whereas PGHS-2 is inducible in monocytes in response to proinflammatory agents. Using freshly
Maria Tsirigotis et al.
PloS one, 3(5), e2130-e2130 (2008-05-08)
The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood. Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation of p38MAPK and that the atypical PKC iota
Gerd Wagner et al.
Medicinal research reviews, 26(1), 1-62 (2005-11-12)
The recent successful introduction of the anti-cytokine biologicals Etanercept, Infliximab, Adalimumab, and Anakinra has stimulated the search for anti-cytokine small-molecules. A number of molecular targets have been identified for the development of such small molecular anti-cytokine agents. The focus of
J C Lee et al.
Immunopharmacology, 47(2-3), 185-201 (2000-07-06)
Since the discovery of p38 MAP kinase in 1994, our understanding of its biology has progressed dramatically. The key advances include (1) identification of p38 MAP kinase homologs and protein kinases that act upstream and downstream from p38 MAP kinase
H Watanabe et al.
The Journal of biological chemistry, 276(17), 14466-14473 (2001-03-30)
In chondrogenesis, members of the transforming growth factor-beta (TGF-beta) superfamily play critical roles by inducing gene expression of cartilage-specific molecules. By using a chondrogenic cell line, ATDC5, we investigated the TGF-beta-mediated signaling pathways involved in expression of the aggrecan gene
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