推荐产品
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
protect from light
颜色
off-white
mp
189-190 °C (lit.)
溶解性
DMSO: soluble >10 mg/mL
储存温度
2-8°C
SMILES字符串
Fc1ccc(cc1)-c2nc3SCCn3c2-c4ccncc4
InChI
1S/C16H12FN3S/c17-13-3-1-11(2-4-13)14-15(12-5-7-18-8-6-12)20-9-10-21-16(20)19-14/h1-8H,9-10H2
InChI key
YOELZIQOLWZLQC-UHFFFAOYSA-N
基因信息
human ... IL1B(3553) , TNF(7124)
rat ... Alox5(25290)
生化/生理作用
p38 MAP kinase inhibitor.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
新产品
M Pouliot et al.
Journal of immunology (Baltimore, Md. : 1950), 158(10), 4930-4937 (1997-05-15)
Prostaglandin endoperoxide synthase (PGHS; cyclooxygenase), the rate-limiting enzyme in the conversion of arachidonic acid to prostanoids, has two isoforms. PGHS-1 is constitutively expressed and involved in homeostasis, whereas PGHS-2 is inducible in monocytes in response to proinflammatory agents. Using freshly
Maria Tsirigotis et al.
PloS one, 3(5), e2130-e2130 (2008-05-08)
The signaling pathways that may modulate the pathogenesis of diseases induced by expanded polyglutamine proteins are not well understood. Herein we demonstrate that expanded polyglutamine protein cytotoxicity is mediated primarily through activation of p38MAPK and that the atypical PKC iota
Donna E Muscarella et al.
Toxicological sciences : an official journal of the Society of Toxicology, 68(1), 82-92 (2002-06-21)
Various forms of inorganic arsenic are significant environmental contaminants that have multiple effects on cells, including the induction of apoptotic cell death. Induction of apoptosis in lymphoid cells can mediate immunotoxicity following exposure to chemicals. However, the mechanisms regulating the
S Su et al.
BioTechniques, 22(6), 1107-1113 (1997-06-01)
We have developed a high-throughput, multiplex reverse transcription PCR (RTPCR) assay that is suitable for the analysis of medium-to low-copy cellular RNA transcripts from small numbers of cells (10(4)). High throughput was attained by utilizing microplate-based RNA extraction and RTPCR
T Ishizuka et al.
Proceedings of the National Academy of Sciences of the United States of America, 94(12), 6358-6363 (1997-06-10)
Mast cells synthesize and secrete specific cytokines and chemokines which play an important role in allergic inflammation. Aggregation of the high-affinity Fc receptor (FcepsilonRI) for immunoglobulin E (IgE) in MC/9 mouse mast cells stimulates the synthesis and secretion of tumor
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