产品名称
人ADAMTS4 ELISA试剂盒, for cell culture supernatants, plasma, and serum samples
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
input
sample type serum sample(s)
sample type plasma
sample type cell culture supernatant(s)
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 0.12 ng/ml
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ADAMTS4(9507)
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached Protocolfor details.
Please refer to the attached Protocolfor details.
General description
Human a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS4) enzyme-linked immunosorbent assay (ELISA) kit is an in vitro ELISA kit for the quantitative measurement of a human ADAMTS4 in biological samples, such as serum, plasma, cell culture supernatants, urine, and/or cell and tissue lysates. ADAMTS4 is a multidomain metalloproteinase that can inhibit the activity of aggrecan. It belongs to the ADAMTS family. ADAMTS4 is made up of a pro-domain, a catalytic metalloproteinase domain, a disintegrin-like (Dis) domain, a thrombospondin type I (TS) domain. It also contains a cysteine-rich (CysR) domain and a spacer (Sp) domain. ADAMTS4 gene is located on the human chromosome at 1q23.3.
This ELISA antibody pair detects Human ADAMTS-4
Other Notes
A sample Certificate of Analysis is available for this product. Please type the word sample in the text box provided for lot number.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Met. Corr. 1
存储类别
8A - Combustible corrosive hazardous materials
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Single-nucleotide polymorphisms in the coding region of a disintegrin and metalloproteinase with thrombospondin motifs 4 and hepatocellular carcinoma: A retrospective case-control study
Wang X Z, et al.
Cancer Medicine, 8(18), 7869-7880 (2019)
Michael Stock et al.
Arthritis & rheumatology (Hoboken, N.J.), 69(6), 1233-1245 (2017-01-14)
Cartilage damage and subchondral bone changes are closely connected in osteoarthritis. Nevertheless, how these processes are interlinked is, to date, incompletely understood. This study was undertaken to investigate the mechanistic role of a cartilage-derived protein, upper zone of growth plate
Functional differences of the catalytic and non-catalytic domains in human ADAMTS-4 and ADAMTS-5 in aggrecanolytic activity
Fushimi K, et al.
The Journal of Biological Chemistry, 283(11), 6706-6716 (2008)
Jianjun Chen et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 46(4), 1693-1703 (2018-04-26)
ADAMTSs (A disintegrin and metalloprotease domains with thrombospondins motifs) are a family of extracellular proteases that have been related to both oncogenic and tumor-suppressive functions. The aim of the present study was to investigate: 1) the mutation, copy-number alterations, and
Jiyun Lee et al.
Experimental & molecular medicine, 52(4), 672-681 (2020-04-22)
Osteoarthritis (OA) is a common joint disease that results from the disintegration of joint cartilage and the underlying bone. Because cartilage and chondrocytes lack the ability to self-regenerate, efforts have been made to utilize stem cells to treat OA. Although
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