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种属反应性
mouse
包装
kit of 96 wells (12 strips x 8 wells)
技术
ELISA: suitable
输入
sample type cell culture supernatant(s)
sample type serum
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 32 pg/mL
standard curve range: 32.77-8000 pg/mL
检测方法
colorimetric
运输
wet ice
储存温度
−20°C
基因信息
mouse ... Lepr(16847)
一般描述
The antibody pair provided in this kit recognizes mouse Leptin Receptor.
应用
请参考Protocol了解详情。
生化/生理作用
Leptin receptor (Lepr) belonging to class I cytokine receptor family, binds with leptin, a small non-glycosylated peptide hormone and transduces signal. Lepr expression is present in brain and immune cells. Signal transduction through Lepr regulates fat metabolism in mammals. Lepr is part of the hematopoietic pathway. Lepr is a marker for mesenchymal stem/stromal cells (MSCs) and regulates the regenerative process of bone and cartilage after injury. Lepr regulates pancreatic β cell functions. Polymorphism in Lepr causes metabolic diseases like obesity, dyslipidemia, hypertension and Type 2 diabetes. Mutations in Lepr associates with polycystic ovarian syndrome (PCOS) susceptibility.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Met. Corr. 1
储存分类代码
8A - Combustible corrosive hazardous materials
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
LEPR gene polymorphism and plasma soluble leptin receptor levels are associated with polycystic ovary syndrome in Han Chinese women
Tu X, et al.
Personalized Medicine, 14(4), 299-307 (2017)
Leptin and leptin receptors in salivary glands of primary Sjogren?s syndrome
Erbasan F, et al.
Pathology Research and Practice, 212(11), 1010-1014 (2016)
Plasma soluble leptin receptor levels are associated with pancreatic beta-cell dysfunction in patients with type 2 diabetes
Morioka T, et al.
Journal of diabetes investigation, 9(1), 55-62 (2018)
Leptin receptor makes its mark on MSCs
Matsuzaki Y, et al.
Cell Stem Cell, 15(2), 112-114 (2014)
A role for leptin and its cognate receptor in hematopoiesis
Bennett BD, et al.
Current Biology, 6(9), 1170-1180 (1996)
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