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About This Item
经验公式（希尔记法）:
C21H27N7O
CAS号:
分子量:
393.49
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
检测方案
≥98% (HPLC)
形式
solid
溶解性
DMSO: soluble 7 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
C1CCC(CC1)Nc2nc(Nc3ccc(cc3)N4CCOCC4)nc5nc[nH]c25
InChI
1S/C21H27N7O/c1-2-4-15(5-3-1)24-20-18-19(23-14-22-18)26-21(27-20)25-16-6-8-17(9-7-16)28-10-12-29-13-11-28/h6-9,14-15H,1-5,10-13H2,(H3,22,23,24,25,26,27)
InChI key
ZFLJHSQHILSNCM-UHFFFAOYSA-N
基因信息
human ... ADORA1(134) , ADORA2A(135) , ADORA2B(136) , ADORA3(140)
rat ... Adora3(25370)
应用
逆转素已被用作单极纺锤体 1 (Mps1) 激酶抑制剂或有丝分裂纺锤体装配检查点 (SAC) 抑制剂：
- 研究康普瑞汀 A4 (CA4) 介导的细胞毒性是否需要有丝分裂阻滞
- 研究 SAC 活化对 eb 病毒 (EBV) 复制的贡献
- 诱导染色体错分
生化/生理作用
逆转素最早被描述为一种合成的取代嘌呤，具有去分化剂的活性；它被证明可以诱导分化的谱系定向细胞成为多潜能间充质干细胞 (MSCs)。还显示出具有强效、选择性人 a 3 腺苷受体拮抗剂的活性（K i 值为 0.66μl）。ATP-竞争性 Aurora 激酶抑制剂，Mps1 激酶抑制剂。此外，研究表明，逆转素是一种抗癌药物，可抑制多种癌细胞的生长并诱导其死亡。
储存及稳定性
根据其他来源，在DMSO中储存的逆转溶液只能在短期内稳定冷藏。对于长期储存，等分试样应在-20°C下稳定保存最长2年。不建议溶液在常温下存放。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
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