产品名称
Monoclonal Anti-Rac antibody produced in mouse, clone 23A8, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
23A8, monoclonal
form
buffered aqueous solution
mol wt
antigen 21 kDa
species reactivity
rat, human, mouse
technique(s)
immunohistochemistry (frozen sections): suitable
immunoprecipitation (IP): suitable
western blot: 0.5-2.0 μg/mL using rat brain microsomal protein preparation
isotype
IgG
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified, unmodified
Quality Level
Gene Information
human ... ARHGEF6(9459)
mouse ... Arhgef6(73341)
rat ... Arhgef6(363509)
Biochem/physiol Actions
The antibody recognizes Rac1 with a slight Rac2 cross-reactivity.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
recombinant protein containing the full length human Rac1.
Physical form
Solution in 0.1 M Tris-glycine, pH 7.4, containing 0.15 M NaCl and 0.05% sodium azide with 30% glycerol.
Preparation Note
Purified using protein G
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Laura Barrio-Real et al.
Oncotarget, 9(47), 28612-28624 (2018-07-10)
Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (P-Rex1) is a key mediator of growth factor-induced activation of Rac1, a small GTP-binding protein widely implicated in actin cytoskeleton reorganization. This Guanine nucleotide Exchange Factor (GEF) is overexpressed in human luminal breast cancer
Michael R Dohn et al.
The Journal of cell biology, 184(3), 437-450 (2009-02-04)
p120-catenin regulates epithelial cadherin stability and has been suggested to function as a tumor suppressor. In this study, we used anchorage-independent growth (AIG), a classical in vitro tumorigenicity assay, to examine the role of p120 in a different context, namely
Matthias Rübsam et al.
Nature communications, 8(1), 1250-1250 (2017-11-03)
Generation of a barrier in multi-layered epithelia like the epidermis requires restricted positioning of functional tight junctions (TJ) to the most suprabasal viable layer. This positioning necessitates tissue-level polarization of junctions and the cytoskeleton through unknown mechanisms. Using quantitative whole-mount
Cheng-Wei Lin et al.
Carcinogenesis, 35(11), 2425-2435 (2014-06-28)
Metastatic disease is the leading cause of cancer mortality. Identifying biomarkers and regulatory mechanisms is important toward developing diagnostic and therapeutic tools against metastatic cancer. In this study, we demonstrated that podocalyxin-like 1 (PODXL) is overexpressed in breast tumor cells
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