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生物来源
human
质量水平
重组
expressed in E. coli K12
检测方案
≥90%
形式
buffered aqueous glycerol solution
比活
≥50,000 units/mg protein
分子量
~250 kDa
UniProt登记号
应用
cell analysis
运输
dry ice
储存温度
−70°C
基因信息
human ... PTPRB(5787)
一般描述
Protein tyrosine phosphatase, receptor type B (PTPRB), also known as vascular endothelial-protein-tyrosine phosphatase (VE-PTP), might have a role in remodeling of blood vessels and in angiogenesis. The gene encoding it is localized on human chromosome 12q15. It is also important for endothelial cell migration. The protein also controls the phosphorylation state of the angiopoietin receptor, Tie-2. PTPRB may modulate sodium channels by influencing the tyrosine phosphorylation status.
生化/生理作用
Dephosphorylates tyrosine proteins.
单位定义
One unit of PTP-β will hydrolyze 1.0 nanomole of p-nitrophenyl phosphate per min at 30 °C.
外形
solution in 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCL, 3 mM DTT, 16 mM glutathione and 20% glycerol
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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INTERNATIONAL CONFERENCE OF COMPUTATIONAL METHODS IN SCIENCES AND ENGINEERING 2009:(ICCMSE 2009). (2016)
Picomolar concentrations of free zinc(II) ions regulate receptor protein-tyrosine phosphatase ? activity.
Wilson M
The Journal of Biological Chemistry (2012)
1002 protein phosphatases?
H Charbonneau et al.
Annual review of cell biology, 8, 463-493 (1992-01-01)
A sodium channel signaling complex: modulation by associated receptor protein tyrosine phosphatase beta.
Ratcliffe CF
Nature Neuroscience (2000)
Shear stress-induced redistribution of vascular endothelial-protein-tyrosine phosphatase (VE-PTP) in endothelial cells and its role in cell elongation.
Mantilidewi KI
The Journal of Biological Chemistry (2014)
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