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Merck
CN

P9405

Sigma-Aldrich

O-磷酸- L -酪氨酸

≥95.0% (HPLC)

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别名:
L -3-(4-羟基苯基)丙氨酸 4′-磷酸盐, L -酪氨酸-O-磷酸盐
经验公式(希尔记法):
C9H12NO6P
CAS号:
分子量:
261.17
Beilstein:
3150815
MDL编号:
UNSPSC代码:
12352209
eCl@ss:
32160406
PubChem化学物质编号:
NACRES:
NA.26

检测方案

≥95.0% (HPLC)

质量水平

形式

powder

颜色

white to off-white

mp

225 °C

应用

cell analysis

储存温度

−20°C

SMILES字符串

N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(O)=O

InChI

1S/C9H12NO6P/c10-8(9(11)12)5-6-1-3-7(4-2-6)16-17(13,14)15/h1-4,8H,5,10H2,(H,11,12)(H2,13,14,15)/t8-/m0/s1

InChI key

DCWXELXMIBXGTH-QMMMGPOBSA-N

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应用

O-磷酸-L-酪氨酸已用于:
  • 作为抗磷酸酪氨酸抗体的稀释剂,研究精子获能
  • 在液相色谱-串联质谱(LC-MS-MS)分析中作为氨基酸标准品
  • 作为氨基酸标准品在二维薄层电泳系统中分析磷酸化淀粉磷酸化酶(L-SP)上的磷酸化氨基酸

生化/生理作用

磷酸酪氨酸作为蛋白质调控的对接位点,通过刺激酪氨酸磷酸化蛋白与其他蛋白的磷酸酪氨酸结构域相互作用。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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Julia Petschnigg et al.
Nature methods, 11(5), 585-592 (2014-03-25)
Cell signaling, one of key processes in both normal cellular function and disease, is coordinated by numerous interactions between membrane proteins that change in response to stimuli. We present a split ubiquitin-based method for detection of integral membrane protein-protein interactions
Chi Hoon Park et al.
BMC cancer, 16, 35-35 (2016-01-24)
c-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has been identified as a good candidate for targeted therapy in gastric cancer.
Bidur Paudel et al.
Biology of reproduction, 100(2), 440-454 (2018-09-22)
Mammalian sperm undergo a series of biochemical and physiological changes collectively known as capacitation in order to acquire the ability to fertilize. Although the increase in phosphorylation associated with mouse sperm capacitation is well established, the identity of the proteins
Guang-Huar Young et al.
Planta, 223(3), 468-478 (2005-09-10)
A 78-amino acid insertion (L78) is found in the low-affinity type (L-form) of starch phosphorylase (L-SP, EC 2.4.1.1). This insertion blocks the starch-binding site on the L-SP molecule, and it decreases the binding affinity of L-SP toward starch. The computational
Taku Yasui et al.
PloS one, 11(11), e0166710-e0166710 (2016-11-20)
Grb2-associated binder (Gab) docking proteins regulate signals downstream of a variety of growth factors and receptor tyrosine kinases. Neuregulin-1 (NRG-1), a member of epidermal growth factor family, plays a critical role for cardiomyocyte proliferation and prevention of heart failure via

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