推荐产品
表单
powder or solid
质量水平
分子量
5,000-25,000
颜色
white to light yellow
应用
cell analysis
储存温度
−20°C
SMILES字符串
[N+H3][C@@H](Cc1[nH]cnc1)C(=O)[O-]
InChI
1S/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1
InChI key
HNDVDQJCIGZPNO-YFKPBYRVSA-N
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相关类别
一般描述
聚-L-组氨酸是一种两性化合物。结构中的咪唑环可进行质子化−去质子化反应。
应用
聚L-组氨酸已用于：
- 作为聚阳离子分散多壁碳纳米管(MWCNT)
- 作为多离子化合物研究其破坏细胞外包膜病毒膜的能力
- 通过在细胞水平上和在体内的抗朊毒体(prion)分析，进行其抗朊毒体活性筛选
生化/生理作用
聚L-组氨酸(Phis)共聚物具有生物相容性、pH响应性和较低的毒性。它具有逃逸内溶酶体的功能。聚L组氨酸与聚乙二醇−聚(d,l-丙交酯) (PEG-PLA)的共聚物可有效递送阿霉素。pH敏感性聚l-组氨酸共聚物胶束可在酸性微环境中递送抗癌药物。
分析说明
分子量 (MALLS)。
其他说明
有关聚氨基酸的其他技术信息，请访问 聚氨基酸常见问题解答资源。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Hongbo Zhang et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(10), 1935-1944 (2012-07-12)
Many laboratories use recombinant UDP-glucuronosyltransferases (UGTs), expressed in baculovirus-infected insect cells, for drug glucuronidation studies. We have infected Sf9 insect cells with increasing amounts of recombinant baculovirus, encoding either UGT1A9 or UGT2B7, and measured both glucuronidation activity and immunodetectable UGT
Yuehua Cong et al.
Bioconjugate chemistry, 23(2), 248-263 (2012-01-17)
The efficacy of protein-based medicines can be compromised by their rapid clearance from the blood circulatory system. Achieving optimal pharmacokinetics is a key requirement for the successful development of safe protein-based medicines. Protein PEGylation is a clinically proven strategy to
Yi-Fang Zeng et al.
Biomaterials, 33(36), 9239-9245 (2012-10-03)
Loading of viral vectors in synthetic polymers is a promising strategy for overcoming hurdles associated with viral gene delivery. For enhanced gene expression at a specific site, gene transfer by using hydrogels represents a versatile approach. In this study, adeno-associated
Pablo R Dalmasso et al.
Biosensors & bioelectronics, 39(1), 76-81 (2012-07-17)
We report for the first time the development of a sensitive and selective glucose biosensor based on the self-assembling of multiwall carbon nanotubes (MWCNTs) dispersed in polyhistidine (Polyhis) and glucose oxidase (GOx) on glassy carbon electrodes (GCE). The supramolecular architecture
Poly (l-histidine) based copolymers: effect of the chemically substituted l-histidine on the physio-chemical properties of the micelles and in vivo biodistribution
Zhang X, et al.
Colloids and Surfaces. B, Biointerfaces, 140(5), 176-184 (2016)
商品
Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.
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