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Merck
CN

P8692

Sigma-Aldrich

Paromomycin sulfate salt 硫酸盐

powder, suitable for plant cell culture, BioReagent

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About This Item

经验公式(希尔记法):
C23H45N5O14 · xH2SO4
CAS号:
分子量:
615.63 (free base basis)
Beilstein:
5715182
UNSPSC代码:
10171502
PubChem化学物质编号:
NACRES:
NA.72

product name

Paromomycin sulfate salt 硫酸盐, suitable for plant cell culture, BioReagent

产品线

BioReagent

质量水平

形式

powder

技术

cell culture | plant: suitable

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

应用

agriculture

作用机制

protein synthesis | interferes

SMILES字符串

O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

InChI

1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key

OYJABWUHUYVDMJ-UDXJMMFXSA-N

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一般描述

Chemical structure: aminoglycoside

应用

Paromomycin, monomycin, is an aminoglycoside antibiotic used to select genetically transformed plants and plant cells.

生化/生理作用

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

包装

5g,25g

其他说明

Keep container tightly closed in a dry and well-ventilated place

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

监管及禁止进口产品

分析证书(COA)

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Takahiko Akematsu et al.
iScience, 23(1), 100749-100749 (2019-12-31)
During sexual reproduction in the ciliate, Tetrahymena thermophila, cells of complementary mating type pair ("conjugate") undergo simultaneous meiosis and fertilize each other. In both mating partners only one of the four meiotic products is "selected" to escape autophagy, and this
Vasundhra Bhandari et al.
PLoS neglected tropical diseases, 6(5), e1657-e1657 (2012-05-26)
With widespread resistance to antimonials in Visceral Leishmaniasis (VL) in the Indian subcontinent, Miltefosine (MIL) has been introduced as the first line therapy. Surveillance of MIL susceptibility in natural populations of Leishmania donovani is vital to preserve it and support
Sarah Hendrickx et al.
PLoS neglected tropical diseases, 6(5), e1664-e1664 (2012-06-06)
Paromomycin (PMM) has recently been introduced for treatment of visceral leishmaniasis in India. Although no clinical resistance has yet been reported, proactive vigilance should be warranted. The present in vitro study compared the outcome and stability of experimental PMM-resistance induction
Kazuki Saito et al.
Nucleic acids research, 43(9), 4591-4601 (2015-04-22)
In eukaryotes, the tRNA-mimicking polypeptide-chain release factor, eRF1, decodes stop codons on the ribosome in a complex with eRF3; this complex exhibits striking structural similarity to the tRNA-eEF1A-GTP complex. Although amino acid residues or motifs of eRF1 that are critical
Félix de Carpentier et al.
Frontiers in plant science, 11, 242-242 (2020-03-27)
Chlamydomonas reinhardtii is a model unicellular organism for basic or biotechnological research, such as the production of high-value molecules or biofuels thanks to its photosynthetic ability. To enable rapid construction and optimization of multiple designs and strains, our team and

商品

Antibiotic kill curve is a dose response experiment in which mammalian cells are subjected to increasing amounts of selection antibiotic

抗生素杀灭曲线是一项剂量响应实验,通过逐渐增大施加在哺乳动物细胞中的备选抗生素剂量进行测定。

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