质量水平
检测方案
≥75% (HPLC)
形式
powder
杂质
<18% water (Karl Fischer)
颜色
white
溶解性
water: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
运输
dry ice
储存温度
−20°C
SMILES字符串
[Na+].[Na+].[Na+].[Na+].O[C@H]1[C@@H](O)[C@H](O[C@@H]1COP(O)([O-])=O)OP([O-])(=O)OP([O-])([O-])=O
InChI
1S/C5H13O14P3.4Na/c6-3-2(1-16-20(8,9)10)17-5(4(3)7)18-22(14,15)19-21(11,12)13;;;;/h2-7H,1H2,(H,14,15)(H2,8,9,10)(H2,11,12,13);;;;/q;4*+1/p-4/t2-,3-,4-,5?;;;;/m1..../s1
InChI key
QZAPPJHVNYCTAX-CKJQBBATSA-J
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L D Gegnas et al.
Bioorganic & medicinal chemistry letters, 8(13), 1643-1648 (1999-01-05)
A series of transition-state analog inhibitors of the D-glutamic acid-adding enzyme (MurD) of bacterial peptidoglycan biosynthesis has been synthesized and evaluated for inhibition of the E. coli enzyme.
P Pacaud et al.
The Journal of physiology, 441, 477-499 (1991-09-01)
1. The action of carbachol, which activates muscarinic receptors, was studied in single patch-clamped cells where free internal calcium concentration in the cell (Cai2+) was estimated using the emission from the dye Indo-1. Cells were dialysed with potassium-free caesium solution
Nisreen Wahwah et al.
Scientific reports, 10(1), 19907-19907 (2020-11-18)
Cisplatin is a mainstay of cancer chemotherapy. It forms DNA adducts, thereby activating poly(ADP-ribose) polymerases (PARPs) to initiate DNA repair. The PARP substrate NAD+ is synthesized from 5-phosphoribose-1-pyrophosphate (PRPP), and we found that treating cells for 6 h with cisplatin reduced
Matthew Bratkowski et al.
Cell reports, 32(5), 107999-107999 (2020-08-07)
The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 Å) and active SARM1 (6.8 Å) and provide mechanistic insight into the tight regulation
Boyuan Wang et al.
Molecular cell, 80(1), 29-42 (2020-08-29)
(p)ppGpp is a nucleotide messenger universally produced in bacteria following nutrient starvation. In E. coli, ppGpp inhibits purine nucleotide synthesis by targeting several different enzymes, but the physiological significance of their inhibition is unknown. Here, we report the structural basis of
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