P7888
DL-炔丙基甘氨酸
cystathionine γ-lyase inhibitor
别名:
2-氨基-4-戊炔酸, PAG
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关于此项目
经验公式（希尔记法）:
C5H7NO2
化学文摘社编号:
分子量:
113.11
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
NACRES:
NA.26
MDL number:
产品名称
DL-炔丙基甘氨酸, cystathionine γ-lyase inhibitor
SMILES string
NC(CC#C)C(O)=O
InChI
1S/C5H7NO2/c1-2-3-4(6)5(7)8/h1,4H,3,6H2,(H,7,8)
InChI key
DGYHPLMPMRKMPD-UHFFFAOYSA-N
assay
≥98% (TLC)
form
powder
color
white
application(s)
cell analysis
storage temp.
−20°C
Quality Level
Application
- 代谢标记策略提高了光热和光动力协同治疗细菌感染伤口的抗菌效率：该研究表明，在光热和光动力疗法中使用ᴅʟ-丙炔甘氨酸的代谢标记策略可提高抗菌效率，从而治疗细菌感染的伤口（Li et al., 2022）。
- 肽聚糖与近红外-II 染料的代谢标记可实现肠道微生物群的体内成像。：该研究利用ᴅʟ-丙炔基甘氨酸进行代谢标记，实现了体内肠道微生物群的近红外II成像，为微生物组研究提供了新的见解（Wang et al., 2020）。
- 硫化氢上调大鼠胃黏膜碳酸氢钠共转运体1、三叶因子1和三叶因子2的mRNA表达。：研究ᴅʟ-丙炔基甘氨酸在上调胃黏膜特定 mRNA 表达中的作用，对胃肠道研究具有重要意义（Cheraghi et al., 2016）。
Biochem/physiol Actions
DL-丙炔甘氨酸（PAG）是胱硫醚γ-裂解酶（GCL）的不可逆抑制剂，该酶是一种参与谷胱甘肽合成 和调节同型半胱氨酸浓度并介导半胱氨酸合成的代谢转硫途径的关键酶。利用PAG治疗动物疾病模型显示其可减轻破坏硫化氢（H2S）形成或作用的疾病的相关症状。
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Carolina P Lima et al.
The Journal of nutrition, 136(8), 2141-2147 (2006-07-22)
The transsulfuration pathway, which aids in regulating homocysteine concentration and mediates cysteine synthesis, may be sensitive to vitamin B-6 status because cystathionine beta-synthase (CBS) and cystathionine gamma-lyase (CGL) require pyridoxal 5'-phosphate (PLP). To assess relations between vitamin B-6 and transsulfuration
Csaba Szabó
Nature reviews. Drug discovery, 6(11), 917-935 (2007-10-20)
Hydrogen sulphide (H2S) is increasingly being recognized as an important signalling molecule in the cardiovascular and nervous systems. The production of H2S from L-cysteine is catalysed primarily by two enzymes, cystathionine gamma-lyase and cystathionine beta-synthase. Evidence is accumulating to demonstrate
Karen P Maruska et al.
The Journal of comparative neurology, 525(3), 610-638 (2016-08-11)
Neural communication depends on release and reception of different neurotransmitters within complex circuits that ultimately mediate basic biological functions. We mapped the distribution of glutamatergic, GABAergic, and cholinergic neurons in the brain of the African cichlid fish Astatotilapia burtoni using
Patrick Grabher et al.
NeuroImage. Clinical, 15, 494-501 (2017-06-27)
Brainstem networks are pivotal in sensory and motor function and in recovery following experimental spinal cord injury (SCI). To quantify neurodegeneration and its relation to clinical impairment in major brainstem pathways and nuclei in traumatic SCI. Quantitative MRI data of
Lambert Nzungize et al.
Journal of drug targeting, 27(9), 1004-1016 (2019-02-08)
Tuberculosis, especially multidrug resistant cases, remains an enormous public health threat. Mycobacterium tuberculosis metC (Rv3340) an enzyme involved in methionine biosynthesis was identified and characterised for antimicrobial susceptibility. We reported that the overexpression of Rv3340 in Mycobacterium smegmatis (Ms_Rv3340) produces
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