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P7762

Sigma-Aldrich

聚L -精氨酸 盐酸盐

mol wt 15,000-70,000

别名:

L-Arginine homopolymer hydrochloride

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About This Item

CAS号:
26982-20-7
MDL编号:
MFCD00166393
UNSPSC代码:
12352209
PubChem化学物质编号:
24898874
NACRES:
NA.26

表单

powder

质量水平

200

分子量

15,000-70,000

颜色

white to off-white

应用

cell analysis

储存温度

−20°C

SMILES字符串

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

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相关类别

一般描述

聚-L-精氨酸盐酸盐(PLA)是一种同型多聚氨基酸。聚L精氨酸盐酸盐相比聚-L-赖氨酸更能增强膜通透性。它可用作药物载体、神经保护剂及用于抗癌免疫制剂。PLA与多肽疫苗混用可促进抗原呈递细胞(APC)介导的T细胞生成并激发免疫兴奋作用。

应用

聚-L-精氨酸盐酸盐已用于：
  • 与isRNA9.2s形成复合物刺激中性粒细胞
  • 在核糖体RNA转染人单核细胞THP-1中使用
  • 包裹海藻酸微囊球

质量

含有3%或更低的鸟氨酸残基。

分析说明

分子量基于前体聚-L-鸟氨酸的粘度。 也由MALLS所测定的。

其他说明

有关聚氨基酸的其他技术信息，请访问 聚氨基酸常见问题解答资源。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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分析证书(COA)

Lot/Batch Number
0000405485
0000381407
0000288374
0000387630
0000364230

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RNA of Enterococcus faecalis strain EC-12 is a major component inducing interleukin-12 production from human monocytic cells
Nishibayashi R, et al.
PLoS ONE, 10(6), e0129806-e0129806 (2015)
Vaccination with poly-L-arginine as immunostimulant for peptide vaccines: induction of potent and long-lasting T-cell responses against cancer antigens
Mattner F, et al.
Cancer Research, 62(5), 1477-1480 (2002)
Factors influencing the mechanical stability of alginate beads applicable for immunoisolation of mammalian cells
Bhujbal SV, et al.
Journal of the Mechanical Behavior of Biomedical Materials, 37, 196-208 (2014)
Neutrophils express distinct RNA receptors in a non-canonical way
Berger M, et al.
The Journal of Biological Chemistry, 287(23), 19409-19417 (2012)
Kotaro Sakamoto et al.
Frontiers in pharmacology, 12, 751587-751587 (2021-11-26)
Worldwide, more than 20 million people suffer from schizophrenia, but effective and definitive new therapeutic drugs/treatments have not been established. Vasoactive intestinal peptide receptor 2 (VIPR2) might be an attractive drug target for the treatment of schizophrenia because both preclinical and
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