质量水平
检测方案
≥98% (TLC)
形式
powder
颜色
white
溶解性
H2O: 50 mg/mL
SMILES字符串
Cl[H].Cl[H].CN1CCN(CC1)CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
InChI
1S/C19H21N5O2.2ClH/c1-22-9-11-23(12-10-22)13-17(25)24-16-7-3-2-5-14(16)19(26)21-15-6-4-8-20-18(15)24;;/h2-8H,9-13H2,1H3,(H,21,26);2*1H
InChI key
FFNMBRCFFADNAO-UHFFFAOYSA-N
基因信息
human ... CHRM1(1128)
一般描述
盐酸哌仑西平是一种抗胆碱能药。它也被认为是抗溃疡药。用于治疗近视、胃及十二指肠溃疡。盐酸哌仑西平诱导毒蕈碱M1受体的二聚化。
应用
盐酸哌仑西平已用于
- 成纤维细胞生长因子受体（FGFR）的反式激活。
- 作为细胞培养的补充剂。
- 用于刺激人成纤维细胞
生化/生理作用
选择性M1毒蕈碱乙酰胆碱受体拮抗剂。
特点和优势
该化合物在受体分类和信号转导手册的 乙酰胆碱受体（毒蕈碱） 页面上有详细描述。想要浏览手册的其他页面， 请单击此处。
该化合物是神经科学研究推荐产品。点击此处 ，查看更多神经科学精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问 sigma.com/discover-bsm。
注意
吸湿性；在室温下干燥储存。
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Ion-paired pirenzepine-loaded micelles as an ophthalmic delivery system for the treatment of myopia
Li Y, et al.
Nanomedicine: Nanotechnology, Biology, and Medicine, 13(6), 2079-2089 (2017)
Pirenzepine promotes the dimerization of muscarinic M1 receptors through a three-step binding process
Ilien B, et al.
The Journal of Biological Chemistry, 13(6), jbc-M109 (2009)
Mariko Iwase et al.
Biological & pharmaceutical bulletin, 40(10), 1654-1660 (2017-10-03)
OTC drugs have an important role in self-medication. However, the pharmacokinetic properties of some OTC drugs have not been fully investigated and reports concerning their drug interactions are insufficient. Several gastrointestinal drugs are available as OTC drugs. Because of their
A Elhusseiny et al.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 19(7), 794-802 (1999-07-21)
Acetylcholine is an important regulator of local cerebral blood flow. There is, however, limited information available on the possible sites of action of this neurotransmitter on brain intraparenchymal microvessels. In this study, a combination of molecular and functional approaches was
Muscarinic acetylcholine type 1 receptor activity constrains neurite outgrowth by inhibiting microtubule polymerization and mitochondrial trafficking in adult sensory neurons
Sabbir MG, et al.
Frontiers in Neuroscience, 12(3), 229-237 (2018)
商品
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