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经验公式(希尔记法):
C17H23N3O · C4H4O4
化学文摘社编号:
分子量:
401.46
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352116
EC Number:
200-422-7
MDL number:
Form:
powder
Quality level:
Quality Level
InChI key
JXYWFNAQESKDNC-BTJKTKAUSA-N
InChI
1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
SMILES string
OC(=O)\C=C/C(O)=O.COc1ccc(CN(CCN(C)C)c2ccccn2)cc1
form
powder
originator
Watson
Gene Information
human ... HRH1(3269)
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Application
马来酸吡拉明盐已:
- 作为 H 1 受体拮抗剂
- 用于处理仙女水母属,然后被注射到小鼠腹腔,防止在在膜结合试验中有内源性组胺释放,
- 从而测定 K i 值;并在比较抑制浓度 (IC 50 ) 研究中通过全细胞膜片钳技术使用
Biochem/physiol Actions
马来酸吡拉明为 H1 组胺受体拮抗剂。马来酸吡拉明诱导脊椎动物睡眠。在 仙女水母属 中,它诱导浓度依赖性休眠。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Physical and biological properties of pyrilamine.
T J Haley
Journal of pharmaceutical sciences, 72(1), 3-12 (1983-01-01)
S Y Yeh
Synapse (New York, N.Y.), 32(4), 301-311 (1999-05-20)
Various effects of chlorpheniramine (CPA), diphenhydramine (DIPH), tripelennamine (TRIP), and pyrilamine (PYRI) on fenfluramine (FEN)-induced depletion of serotonin in the brain of rats were observed to be dependent on body temperature. Levels of 5-HT and 5-HIAA in the frontal cortex
The jellyfish Cassiopea exhibits a sleep-like state
Nath RD, et al.
Current Biology, 27(19), 2984-2990 (2017)
Evaluating Vascular Hyperpermeability-inducing Agents in the Skin with the Miles Assay
Brash JT, et al.
Journal of Visualized Experiments, 27(136), e57524-e57524 (2018)
The [3H] dofetilide binding assay is a predictive screening tool for hERG blockade and proarrhythmia: Comparison of intact cell and membrane preparations and effects of altering [K+] o
Diaz GJ, et al.
Journal of Pharmacological and Toxicological Methods, 50(3), 187-199 (2004)
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