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安全信息

P5057

Sigma-Aldrich

Paromomycin sulfate salt 硫酸盐

powder, suitable for cell culture, BioReagent

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About This Item

经验公式（希尔记法）:
C23H45N5O14 · xH2SO4
CAS号:
1263-89-4
分子量:
615.63 (free base basis)
Beilstein:
5715182
UNSPSC代码:
12352207
PubChem化学物质编号:
24898585
NACRES:
NA.76

产品名称

Paromomycin sulfate salt 硫酸盐, powder, BioReagent, suitable for cell culture, potency: ≥675 μg per mg

产品线

BioReagent

质量水平

200

表单

powder

效能

≥675 μg per mg

技术

cell culture | mammalian: suitable

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria

作用机制

protein synthesis | interferes

SMILES字符串

O[C@H]1[C@H](O)[C@@H](CO)O[C@H](O[C@@]2([H])[C@H](O[C@@]3([H])[C@H](O)[C@H](O[C@]4([H])[C@H](N)[C@@H](O)[C@H](O)[C@H](CN)O4)[C@@H](CO)O3)[C@@H](O)[C@H](N)C[C@@H]2N)[C@@H]1N.C

InChI

1S/C23H45N5O14.CH4/c24-2-7-13(32)15(34)10(27)21(37-7)41-19-9(4-30)39-23(17(19)36)42-20-12(31)5(25)1-6(26)18(20)40-22-11(28)16(35)14(33)8(3-29)38-22;/h5-23,29-36H,1-4,24-28H2;1H4/t5-,6+,7+,8-,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1

InChI key

OYJABWUHUYVDMJ-UDXJMMFXSA-N

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相关类别

一般描述

Chemical structure: aminoglycoside
Paromomycin or aminosidine, an aminoglycoside belongs to the class of aminoglycosides. This nonabsorbable antibiotic is found at high level in the lumen of the colon.

应用

  • Paromomycin sulfate salt has been used as a:
  • reference compound in antileishmanial activity
  • RNA-binding ligand and interacts with aptamer. This interaction prevents the binding (and cutting) of dicer to RNA duplex.
Recommended for use in cell culture applications at 100mg/L.
Paromomycin sulfate salt has been used as a positive control to compare the purine analog antiviral 2′,3′-dideoxyinosine (ddI).

生化/生理作用

Antimicrobial spectrum: Gram-negative and Gram-positive bacteria, some protozoan species, and limited antihelminth.
Mode of Action: Inhibits initiation and elongation during protein synthesis.
Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.
Paromomycin possesses antileishmanial and antibacterial activities. It is used to cure visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL). This aminocyclitol glycoside is active against gram-negative and gram-positive bacteria. It is also active against E. histolytica, D. fragilis and several cestodes, like Taenia saginata, Taenia solium etc.

其他说明

1g,5g
Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000360817
0000347037
0000307896
0000347037
0000360817

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访问文档库

Paromomycin
Davidson RN, et al.
Transactions of the Royal Society of Tropical Medicine and Hygiene, 103(7), 653-660 (2009)
Use of a non-adherent cell culture system for testing the effect of 2,3'-dideoxyinosine against Cryptosporidium parvum
Lawton P, et al.
FEMS Microbiology Letters, 176(1), 235-240 (1999)
Leishmaniasis
Manson's Tropical Infectious Diseases (2014)
Antiparasitic Agents
Infectious Diseases, 2, 1345-1372 (2017)
Nanoarchitectures for Neglected Tropical Protozoal Diseases: Challenges and State of the Art
Nano- and Microscale Drug Delivery Systems, 439-480 (2017)
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