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Merck
CN

P4663

聚L -精氨酸 盐酸盐

mol wt 5,000-15,000

别名:

L-Arginine homopolymer hydrochloride

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关于此项目

化学文摘社编号:
26982-20-7
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
24898490
NACRES:
NA.26
MDL number:
MFCD00166393

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产品名称

聚L -精氨酸 盐酸盐, mol wt 5,000-15,000

SMILES string

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

form

powder

mol wt

5,000-15,000

color

white to off-white

application(s)

cell analysis
detection

storage temp.

−20°C

Quality Level

200

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Analysis Note

分子量基于前体聚-L-鸟氨酸的粘度。
含有3%或更低的鸟氨酸残基。

Application


  • 聚（乙烯基胺盐酸盐）、聚（二烯丙基二甲基氯化铵）、聚-L-赖氨酸和聚-L-精氨酸与脂质双分子层相互作用的界面静电。：该研究调查了聚-L-精氨酸盐酸盐与脂质双分子层之间的相互作用，为其在药物输送系统中的潜在应用提供了深入见解（McGeachy et al., 2018）。（McGeachy et al., 2018）。

Other Notes

有关聚氨基酸的其他技术信息，请访问 聚氨基酸常见问题解答资源。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000439673
0000439673
0000473518
0000473518
0000436295

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Analysis of transient and reversible effects of poly-L-arginine on the in vivo nasal absorption of FITC-dextran in rats.
Ohtake K, Natsume H, Ueda H, et al.
J. Controlled Release, 82, 263-275 (2002)
Ramsha Aamir et al.
International journal of molecular sciences, 22(21) (2021-11-14)
Ischemic stroke is the most common type of stroke and thrombolytic therapy is the only approved treatment. However, current thrombolytic therapy with tissue plasminogen activator (tPA) is often hampered by the increased risk of hemorrhage. Plasmin, a direct fibrinolytic, has
Poly-L-arginine enhances paracellular permeability via serine/threonine phosphorylation of ZO-1 and tyrosine dephosphorylation of occludin in rabbit nasal epithelium.
Ohtake K, Maeno T, Ueda H, et al.
Pharmaceut. Res., 20, 1838-1845 (2003)
M Miyamoto et al.
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 52(1), 21-30 (2001-07-05)
The effects of the concentration and molecular weight of poly-L-arginine (poly-L-Arg) on the in vivo nasal absorption of fluorescein isothiocyanate-labeled dextran (MW, 4 kDa, FD-4) in rats were studied. When poly-L-Arg with a range of different molecular weights (MW, 8.9
Julia Wegner et al.
Scientific reports, 11(1), 14983-14983 (2021-07-24)
Antigen-presenting myeloid cells like monocytes detect invading pathogens via pattern recognition receptors (PRRs) and initiate adaptive and innate immune responses. As analysis of PRR signaling in primary human monocytes is hampered by their restricted expandability, human monocyte models like THP-1 cells
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Poly(Amino Acid) Block Copolymers for Drug Delivery and other Biomedical Applications

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