所有图片(2)
别名:
TPEN
经验公式（希尔记法）:
C26H28N6
CAS号:
分子量:
424.54
Beilstein:
4211982
MDL编号:
UNSPSC代码:
12352116
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
形式
powder
质量水平
SMILES字符串
C(CN(Cc1ccccn1)Cc2ccccn2)N(Cc3ccccn3)Cc4ccccn4
InChI
1S/C26H28N6/c1-5-13-27-23(9-1)19-31(20-24-10-2-6-14-28-24)17-18-32(21-25-11-3-7-15-29-25)22-26-12-4-8-16-30-26/h1-16H,17-22H2
InChI key
CVRXLMUYFMERMJ-UHFFFAOYSA-N
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应用
N,N,N′,N′-四（2-吡啶甲基）乙二胺用于：
- 处理人胚肾（HEK293T）细胞，评估其对Jembrana病病毒（JDV）病毒感染因子（Vif）功能的作用
- 在P19胚胎癌细胞中，螯合细胞凋亡过程中释放的锌离子
- 评估其对细胞慢病毒Vpx感染人单核THP-1细胞的作用
生化/生理作用
N,N,N′,N′-四（2-吡啶甲基）乙二胺（TPEN）通过抑制一氧化氮信号传导和Zn2+ 信号传导，引起人急性早幼粒细胞 NB4细胞中的促凋亡作用。在锌预处理的小胶质细胞中，TPEN抑制白介素6分泌和一氧化氮合酶（iNOS）mRNA表达。通过激活人结肠癌细胞中的ATM（毛细血管扩张性共济失调突变）和ATR（ATM-Rad3相关）信号传导，诱导DNA结构受损。
TPEN是一种可透过膜的锌螯合剂；可降低细胞内锌水平并诱导细胞凋亡（即细胞收缩和凋亡小体的形成、DNA片段化和形成典型的DNA梯状带）。
特点和优势
该化合物是细胞凋亡研究的推荐产品。点击这里 发现更多精选的细胞凋亡产品。了解更多有关用于其他研究领域的生物活性小分子的信息，请访问 sigma.com/discover-bsm。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Synthesis of a highly Zn 2+-selective cyanine-based probe and its use for tracing endogenous zinc ions in cells and organisms
Guo Z, et al.
Nature Protocols, 9(6), 1245-1245 (2014)
Elodie Mattio et al.
Talanta, 183, 201-208 (2018-03-24)
In recent years, the development of 3D printing in flow analysis has allowed the creation of new systems with various applications. Up to now, 3D printing was mainly used for the manufacture of small units such as flow detection cells
Zinc depletion by TPEN induces apoptosis in human acute promyelocytic NB4 cells
Zhu B, et al.
Cellular Physiology and Biochemistry, 42(5), 1822-1836 (2017)
Inhibition of Vpx-mediated SAMHD1 and Vpr-mediated HLTF degradation by selective disruption of viral CRL4 (DCAF1) E3 ubiquitin ligase assembly
Wang H, et al.
Journal of Virology, JVI-00225 (2017)
Xin Li et al.
Frontiers in molecular neuroscience, 10, 414-414 (2018-01-10)
Transient receptor potential melastatin-related 2 (TRPM2) channel, a molecular sensor for reactive oxygen species (ROS), plays an important role in cognitive dysfunction associated with post-ischemia brain damage thought to result from ROS-induced TRPM2-dependent neuronal death during reperfusion. Emerging evidence further
商品
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
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