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Merck
CN
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文件

P3892

Sigma-Aldrich

聚L -精氨酸 盐酸盐

suitable for bioconjugations, Mol wt >70,000

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别名:
L-Arginine homopolymer hydrochloride
CAS号:
26982-20-7
MDL编号:
MFCD00166393
UNSPSC代码:
12352209
PubChem化学物质编号:
24898466
NACRES:
NA.26

形式

powder or solid

质量水平

200

分子量

>70,000

技术

bioconjugation: suitable

颜色

white to off-white

储存温度

−20°C

SMILES字符串

Cl.NC(CCCNC(N)=N)C(O)=O

InChI

1S/C18H38N12O4.ClH/c19-10(4-1-7-26-16(20)21)13(31)29-11(5-2-8-27-17(22)23)14(32)30-12(15(33)34)6-3-9-28-18(24)25;/h10-12H,1-9,19H2,(H,29,31)(H,30,32)(H,33,34)(H4,20,21,26)(H4,22,23,27)(H4,24,25,28);1H/t10-,11-,12-;/m0./s1

InChI key

PQEISBBDIRAKGR-LFELFHSZSA-N

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应用

Poly-L-arginine hydrochloride has been used:
  • as polyelectrolyte solution in the synthesis of biodegradable capsules
  • as layer constituent, in the preparation of layer by layer (LbL) assembly of multilayer biodegradable shells
  • in assay for the determination of binding activity of C-reactive protein for polycationic ligands

生化/生理作用

Poly-L-arginine (PLA) possesses anti-bacterial activity. It has a greater capacity to enhance membrane permeability. PLA at lower concentration enhances cell proliferation and at higher concentration acts as antiproliferative agent.

质量

Contains 3% or less ornithine residue by TLC.

分析说明

Molecular weight based on viscosity of precursor poly-L-ornithine.

其他说明

有关聚氨基酸的其他技术信息，请访问 聚氨基酸常见问题解答资源。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Interaction of Calcium-bound C-reactive Protein with Fibronectin Is Controlled by pH IN VIVO IMPLICATIONS
Suresh MV, et al.
Test, 279(50), 52552-52557 (2004)
Poly-L-arginine: Enhancing Cytotoxicity and Cellular Uptake of Doxorubicin and Necrotic Cell Death
Movafegh B, et al.
Anticancer Agents in Medicinal Chemistry, 18(10), 1448-1456 (2018)
NIR-light triggered delivery of macromolecules into the cytosol
Carregal-Romero S, et al.
Journal of Controlled Release : Official Journal of the Controlled Release Society, 159(1), 120-127 (2012)
Multilayered Magnetic Nanobeads for the Delivery of Peptides Molecules Triggered by Intracellular Proteases
Quarta A, et al.
ACS Applied Materials & Interfaces, 9(40), 35095-35104 (2017)
Antibacterial activity of poly-l-arginine under different conditions
Sepahi M , et al.
Iranian Journal of Microbiology, 9(2), 103-103 (2017)
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