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文件

P3584

L-α-Phosphatidyl-D-myo-inositol 4,5-diphosphate, dioctanoyl

Name: <SC>L</SC>-α-Phosphatidyl-<SC>D</SC>-<I>myo</I>-inositol 4,5-diphosphate, dioctanoyl
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₂₅H₄₉O₁₉P₃

CAS号:

204858-53-7

分子量:

746.57

MDL编号:

MFCD02259161

UNSPSC代码:

12352207

PubChem化学物质编号:

24898428

NACRES:

NA.77

形式

powder

质量水平

100

溶解性

H₂O: soluble

储存温度

−20°C

SMILES字符串

CCCCCCCC(=O)OC[C@H](COP(O)(=O)O[C@@H]1[C@H](O)[C@H](O)[C@@H](OP(O)(O)=O)[C@H](OP(O)(O)=O)[C@H]1O)OC(=O)CCCCCCC

InChI

1S/C25H49O19P3/c1-3-5-7-9-11-13-18(26)39-15-17(41-19(27)14-12-10-8-6-4-2)16-40-47(37,38)44-23-20(28)21(29)24(42-45(31,32)33)25(22(23)30)43-46(34,35)36/h17,20-25,28-30H,3-16H2,1-2H3,(H,37,38)(H2,31,32,33)(H2,34,35,36)/t17-,20-,21+,22+,23-,24-,25-/m1/s1

InChI key

XLNCEHRXXWQMPK-MJUMVPIBSA-N

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

底物

Signaling lipid which apparently acts by binding to pleckstrin homology domains; direct activator of inward rectifier potassium channels; phospholipase C and PI3-kinase substrate; activates phospholipase D.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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Glycoprotein D of HSV-1 is dependent on tegument protein UL16 for packaging and contains a motif that is differentially required for syncytia formation.

Jillian C Carmichael et al.

Virology, 527, 64-76 (2018-11-23)

Glycoprotein D (gD) of herpes simplex virus type 1 (HSV-1) plays a key role in multiple events during infection including virus entry, cell-to-cell spread, and virus-induced syncytia formation. Here, we provide evidence that an arginine/lysine cluster located at the transmembrane-cytoplasm

Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma.

C L Huang et al.

Nature, 391(6669), 803-806 (1998-03-05)

Inward rectifier K+ channels, which modulate electrical activity in many cell types, are regulated by protein kinases, guanine-nucleotide-binding proteins (G proteins) and probably actin cytoskeleton. Generation of phosphatidylinositol 4,5-bisphosphate (PIP2) by ATP-dependent lipid kinases is known to activate inward rectifier

Pleckstrin homology domain-mediated membrane association and activation of the beta-adrenergic receptor kinase requires coordinate interaction with G beta gamma subunits and lipid.

J A Pitcher et al.

The Journal of biological chemistry, 270(20), 11707-11710 (1995-05-19)

The pleckstrin homology (PH) domain is an approximately 100-amino-acid region of sequence homology present in numerous proteins of diverse functions, which forms a discrete structural module. Several ligands capable of binding to PH domain-containing proteins have been identified including phosphatidylinositol

Structural characterization of the interaction between a pleckstrin homology domain and phosphatidylinositol 4,5-bisphosphate.

J E Harlan et al.

Biochemistry, 34(31), 9859-9864 (1995-08-08)

The pleckstrin homology (PH) domain is a protein module of approximately 100 amino acids that is found in several proteins involved in signal transduction [for a recent review, see Gibson et al. (1994) Trends Biochem. Sci. 19, 349-353]. Although the

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