产品名称
抗聚谷氨酰胺抗体，小鼠单克隆 小鼠抗, ~2 mg/mL, clone 3B5H10, purified from hybridoma cell culture
biological source
mouse
conjugate
unconjugated
antibody form
purified from hybridoma cell culture
antibody product type
primary antibodies
clone
3B5H10, monoclonal
form
buffered aqueous solution
species reactivity
human
packaging
antibody small pack of 25 μL
concentration
~2 mg/mL
technique(s)
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using extract of HEK-293T cells transfected with an N-terminal 171 amino acid fragment of human Huntingtin with a 68 glutamine stretch
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... HTT(3064)
Application
抗多聚谷氨酰胺单克隆抗体可用于ELISA、免疫印迹和狭缝印迹实验。也可用于免疫沉淀和免疫细胞化学分析。
此抗体已成功使用的应用，以及相关的同行评审论文如下。
蛋白免疫分析（1篇文章）
蛋白免疫分析（1篇文章）
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
General description
异常延长的CAG（或CAA）密码子生成超过临界阈值的谷氨酰胺残基重复序列，导致神经退行性疾病。小鼠抗多聚谷氨酰胺单克隆抗体可用于检测多聚谷氨酰胺蛋白表达。适合蛋白质免疫印迹分析。抗多聚谷氨酰胺单克隆抗体特异性识别同聚多聚谷氨酰胺，不受种属影响。
Immunogen
GST-human Huntingtin（含有 65Q 的 171 个氨基酸的 N 端片段）。
Legal Information
本品仅供 体外 使用。不得用于商业用途。禁止使用本产品生产用于销售或用于诊断、治疗或药物发现等用途。为了获得将本产品用于商业目的的许可证请联系加利福尼亚大学董事会。本产品在美国专利号 6,291,652许可证下出售，专利归加利福尼亚大学董事会所有。
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
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存储类别
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
常规特殊物品
此项目有
Elizabeth Brooks et al.
Methods in molecular biology (Clifton, N.J.), 277, 103-128 (2004-06-18)
Expansion of a homomeric stretch of glutamine residues beyond a critical threshold can produce neurodegenerative disease. This observation led to the idea that abnormal polyglutamine stretches can alter protein structure in ways that contribute to disease. Because they are prone
Amy L Lee et al.
PloS one, 12(3), e0173644-e0173644 (2017-03-11)
Expanded polyglutamine repeats in different proteins are the known determinants of at least nine progressive neurodegenerative disorders whose symptoms include cognitive and motor impairment that worsen as patients age. One such disorder is Huntington's Disease (HD) that is caused by
Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer.
Wacker JL, Zareie MH
Nature Structural and Molecular Biology, 11(12), 1215-1222 (2001)
Veena Prahlad et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(34), 14204-14209 (2011-08-17)
The consequence of chronic protein misfolding is the basis of many human diseases. To combat the deleterious effects of accumulated protein damage, all cells possess robust quality-control systems, specifically molecular chaperones and clearance machineries, that sense and respond to protein
Nicholas R Franich et al.
Journal of neuroscience research, 97(12), 1590-1605 (2019-07-10)
Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expanded CAG repeat within the huntingtin (HTT) gene. The Q140 and HdhQ150 knock-in HD mouse models were generated such that HdhQ150 mice have an expanded CAG repeat inserted into
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