推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified from hybridoma cell culture
抗体产品类型
primary antibodies
克隆
3B5H10, monoclonal
表单
buffered aqueous solution
种属反应性
human
包装
antibody small pack of 25 μL
浓度
~2 mg/mL
技术
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
western blot: 1-2 μg/mL using extract of HEK-293T cells transfected with an N-terminal 171 amino acid fragment of human Huntingtin with a 68 glutamine stretch
同位素/亚型
IgG1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... HTT(3064)
一般描述
异常延长的CAG（或CAA）密码子生成超过临界阈值的谷氨酰胺残基重复序列，导致神经退行性疾病。小鼠抗多聚谷氨酰胺单克隆抗体可用于检测多聚谷氨酰胺蛋白表达。适合蛋白质免疫印迹分析。抗多聚谷氨酰胺单克隆抗体特异性识别同聚多聚谷氨酰胺，不受种属影响。
免疫原
GST-human Huntingtin（含有 65Q 的 171 个氨基酸的 N 端片段）。
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
法律信息
本品仅供 体外 使用。不得用于商业用途。禁止使用本产品生产用于销售或用于诊断、治疗或药物发现等用途。为了获得将本产品用于商业目的的许可证请联系加利福尼亚大学董事会。本产品在美国专利号 6,291,652许可证下出售，专利归加利福尼亚大学董事会所有。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Hsp70 and Hsp40 attenuate formation of spherical and annular polyglutamine oligomers by partitioning monomer.
Wacker JL, Zareie MH
Nature Structural and Molecular Biology, 11(12), 1215-1222 (2001)
Xuan Zhang et al.
Cellular and molecular neurobiology, 36(3), 459-470 (2016-03-10)
In Huntington's disease (HD) the imperfect expanded CAG repeat in the first exon of the HTT gene leads to the generation of a polyglutamine (polyQ) protein, which has some neuronal toxicity, potentially mollified by formation of aggregates. Accumulated research, reviewed
Veena Prahlad et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(34), 14204-14209 (2011-08-17)
The consequence of chronic protein misfolding is the basis of many human diseases. To combat the deleterious effects of accumulated protein damage, all cells possess robust quality-control systems, specifically molecular chaperones and clearance machineries, that sense and respond to protein
Elizabeth Brooks et al.
Methods in molecular biology (Clifton, N.J.), 277, 103-128 (2004-06-18)
Expansion of a homomeric stretch of glutamine residues beyond a critical threshold can produce neurodegenerative disease. This observation led to the idea that abnormal polyglutamine stretches can alter protein structure in ways that contribute to disease. Because they are prone
Amy L Lee et al.
PloS one, 12(3), e0173644-e0173644 (2017-03-11)
Expanded polyglutamine repeats in different proteins are the known determinants of at least nine progressive neurodegenerative disorders whose symptoms include cognitive and motor impairment that worsen as patients age. One such disorder is Huntington's Disease (HD) that is caused by
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