HTT
huntingtin
别名:
HD, IT15
物种:
Human HTT (3064), Mouse Htt (15194), Rat Htt (29424), chicken HTT (422878), Zebrafish htt (30214), fruit fly htt (43392), dog HTT (479074), cow HTT (615059), domestic cat HTT (101086476), naked mole-rat Htt (101697599)
UniProtKB ID:
基因ID:
- Human(3064) Summary: Huntingtin is a disease gene linked to Huntington's disease, a neurodegenerative disorder characterized by loss of striatal neurons. This is thought to be caused by an expanded, unstable trinucleotide repeat in the huntingtin gene, which translates as a polyglutamine repeat in the protein product. A fairly broad range in the number of trinucleotide repeats has been identified in normal controls, and repeat numbers in excess of 40 have been described as pathological. The huntingtin locus is large, spanning 180 kb and consisting of 67 exons. The huntingtin gene is widely expressed and is required for normal development. It is expressed as 2 alternatively polyadenylated forms displaying different relative abundance in various fetal and adult tissues. The larger transcript is approximately 13.7 kb and is expressed predominantly in adult and fetal brain whereas the smaller transcript of approximately 10.3 kb is more widely expressed. The genetic defect leading to Huntington's disease may not necessarily eliminate transcription, but may confer a new property on the mRNA or alter the function of the protein. One candidate is the huntingtin-associated protein-1, highly expressed in brain, which has increased affinity for huntingtin protein with expanded polyglutamine repeats. This gene contains an upstream open reading frame in the 5' UTR that inhibits expression of the huntingtin gene product through translational repression. [provided by RefSeq, Jul 2008]
- Mouse(15194) huntingtin
- Rat(29424) huntingtin
- chicken(422878) huntingtin
- Zebrafish(30214) huntingtin
- fruit fly(43392) huntingtin
- dog(479074) huntingtin
- cow(615059) huntingtin
- domestic cat(101086476) huntingtin
- naked mole-rat(101697599) huntingtin
- domestic guinea pig(100713322) huntingtin
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Antibodies
货号
说明
物种反应性
应用
Anti-Htt Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
物种反应性
human
应用
immunohistochemistry
抗-polyQ疾病蛋白抗体（克隆3B5H10）, clone 3B5H10, from mouse,
物种反应性
human
应用
electron microscopy
immunocytochemistry
immunohistochemistry
inhibition assay
western blot
immunocytochemistry
immunohistochemistry
inhibition assay
western blot
抗聚谷氨酰胺抗体，小鼠单克隆 小鼠抗, ~2 mg/mL, clone 3B5H10, purified from hybridoma cell culture,
物种反应性
human
应用
immunocytochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Huntingtin Protein Antibody, clone 1M11, ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
物种反应性
human, mouse, rat
应用
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-Huntingtin Antibody, a.a. 115-129 Antibody, clone 5HU-1H6, ,
物种反应性
human
应用
immunocytochemistry
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot