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P101

Sigma-Aldrich

2-Phenylaminoadenosine

>97%, solid

别名:

CV-1808

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About This Item

经验公式（希尔记法）:
C16H18N6O4
CAS号:
53296-10-9
分子量:
358.35
MDL编号:
MFCD00055119
UNSPSC代码:
12352200
PubChem化学物质编号:
24277727
NACRES:
NA.77

质量水平

100

方案

>97%

表单

solid

颜色

white

溶解性

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 3.6 mg/mL
H2O: insoluble
absolute ethanol: slightly soluble
ethanol: water (1:1): soluble
methanol: soluble (hot)

储存温度

−20°C

SMILES字符串

Nc1nc(Nc2ccccc2)nc3n(cnc13)[C@@H]4O[C@H](CO)[C@@H](O)[C@H]4O

InChI

1S/C16H18N6O4/c17-13-10-14(21-16(20-13)19-8-4-2-1-3-5-8)22(7-18-10)15-12(25)11(24)9(6-23)26-15/h1-5,7,9,11-12,15,23-25H,6H2,(H3,17,19,20,21)/t9-,11-,12-,15-/m1/s1

InChI key

SCNILGOVBBRMBK-SDBHATRESA-N

基因信息

human ... ADORA2A(135) , ADORA2B(136)
rat ... Adora1(29290) , Adora2a(25369)

生化/生理作用

Selective A2 adenosine receptor agonist; potent coronary vasodilator; weak inhibitor of adenosine uptake by rat cerebral cortical synaptosomes.

重悬

Solutions should be freshly prepared.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
078H4661V

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D A Taylor et al.
European journal of pharmacology, 85(3-4), 335-338 (1982-12-03)
2-Chloroadenosine (2-CADO) and 2-phenylaminoadenosine (CV 1808) were compared in a CNS purinergic receptor binding assay and the inhibition of neurogenic contractions of the vas deferens. Both 2-CADO and CV 1808 are more potent than adenosine in both preparations. CV 1808
J W Phillis et al.
Pharmacology, biochemistry, and behavior, 24(2), 263-270 (1986-02-01)
Mice were implanted with chronic indwelling cannulae in the lateral cerebral ventricle. A series of adenosine analogs and related compounds were injected into the lateral ventricle (ICVT) and their effects on spontaneous locomotor activity recorded. All analogs produced dose-related decreases
P H Wu et al.
General pharmacology, 15(3), 251-254 (1984-01-01)
Various adenosine derivatives, methylxanthines and other compounds were tested for their abilities to inhibit the rapid uptake of adenosine by rat cerebral cortical synaptosomes. Several pharmacologically potent derivatives of adenosine were weak inhibitors of uptake with IC20 values in excess
Stimulation of Adenosine A
Sarawuth Phosri et al.
Frontiers in pharmacology, 8, 428-428 (2017-07-18)
Mark Soave et al.
SLAS discovery : advancing life sciences R & D, 25(2), 186-194 (2019-10-05)
Receptor internalization in response to prolonged agonist treatment is an important regulator of G protein-coupled receptor (GPCR) function. The adenosine A1 receptor (A1AR) is one of the adenosine receptor family of GPCRs, and evidence for its agonist-induced internalization is equivocal.

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