一般描述
主要用于匀浆后细胞核保持完整的细胞工作。
特点和优势
• Manufactured from borosilicate glass 3.3• Designed primarily for cellular work where the nucleus remains intact after homogenization.• All-glass construction• Two pestles are supplied with each complete unit• Large clearance pestle is used for the initial sample reduction• Small clearance pestle is used to form the final homogenate• Replacement components are available and completely interchangeable
Yuezhou Wang et al.
Cell chemical biology, 27(11), 1359-1370 (2020-07-11)
Multidrug resistance (MDR) in cancer remains a major challenge for the success of chemotherapy. Natural products have been a rich source for the discovery of drugs against MDR cancers. Here, we applied high-throughput cytotoxicity screening of an in-house natural product
Yue Zong et al.
Cell research, 29(6), 460-473 (2019-04-06)
AMPK, a master regulator of metabolic homeostasis, is activated by both AMP-dependent and AMP-independent mechanisms. The conditions under which these different mechanisms operate, and their biological implications are unclear. Here, we show that, depending on the degree of elevation of
Mengqi Li et al.
Cell metabolism, 30(3), 508-524 (2019-06-18)
Fructose-1,6-bisphosphate (FBP) aldolase links sensing of declining glucose availability to AMPK activation via the lysosomal pathway. However, how aldolase transmits lack of occupancy by FBP to AMPK activation remains unclear. Here, we show that FBP-unoccupied aldolase interacts with and inhibits
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