P0090
Anti-PMP70−Atto 488 兔抗
1.5-3 mg/mL, affinity isolated antibody, buffered aqueous solution
别名:
Anti-70 kDa Peroxisonal membrane protein, Anti-ABCD3, Anti-PXMP1
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关于此项目
Conjugate:
Atto 488 conjugate
Clone:
polyclonal
Application:
IF (d)
Citations:
11
biological source
rabbit
conjugate
Atto 488 conjugate
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
rat, mouse, human
packaging
antibody small pack of 25 μL
storage condition
protect from light
concentration
1.5-3 mg/mL
technique(s)
direct immunofluorescence: 10-20 μg/mL using human HeLa cells
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ABCD3(5825)
mouse ... Abcd3(19299)
rat ... Abcd3(25270)
General description
70 kDa peroxisomal membrane protein (PMP70) belongs to the adrenoleukodystrophy (ALD) subfamily of the ATP-binding cassette (ABC) transporter superfamily. It is a half-size ABC integral membrane protein consisting of 6 transmembrane domains and one ATP-binding domain.
ATP-binding cassette sub-family D member 3 (ABCD3) is a peroxisomal membrane protein belonging to an ATP binding cassette family. The gene encoding it is localized on human chromosome 1p21-22 and rat chromosome 2q41.
Immunogen
synthetic peptide corresponding to amino acid residues 644-659 of rat PMP70 conjugated to KLH. The corresponding sequence is identical in mouse and differs by one amino acid in human.
Application
Atto 488 antibody produced in rabbit has been used in immunofluorescence.
Biochem/physiol Actions
70 kDa peroxisomal membrane protein (PMP70) forms a stable complex with the adrenoleukodystrophy protein, (ALDP), and several other peroxisomal proteins. ATP-binding/hydrolysis by PMP70 and ALDL and their phosphorylation are involved in the regulation of fatty acid transport into peroxisomes. Mutations in the PMP70 (PXMP1) gene may cause a subset of Zellweger syndrome-2, an autosomal recessive disorder that is manifested by a defective import mechanisms for peroxisomal matrix enzymes.
ATP-binding cassette sub-family D member 3 (ABCD3) is responsible for the transport of fatty acids into peroxisomes by an ATP-dependent mechanism. It also participates in the oxidation of dicarboxylic acids. Defects in the protein activity result in hepatosplenomegaly, a liver disease. Change in the expression of ABCD3 is associated with prostate tumor aggressiveness and a deficiency of the protein causes bile acid biosynthesis defect.
Physical form
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
12 - Non Combustible Liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
此项目有
Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes
Biermanns M and Gartner J
Biochemical and Biophysical Research Communications, 285(3), 649-655 (2001)
Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization.
Kielar D
The Journal of Investigative Dermatology (2003)
RNAi-mediated silencing of ABCD3 gene expression in rat C6 glial cells: A model system to study PMP70 function
Rita Di
Neurochemistry International (2008)
ABC Transporter Subfamily D: Distinct Differences in Behavior between ABCD1-3 and ABCD4 in Subcellular Localization, Function, and Human Disease.
Kawaguchi K and Morita M
BioMed Research International (2016)
Immunohistological analysis of ABCD3 expression in Caucasian and African American prostate tumors.
Reams RR
BioMed Research International (2015)
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