O9126
Oxotremorine sesquifumarate salt
≥98% (HPLC), solid
别名:
1-(4-[1-Pyrrolidinyl]-2-butynyl)-2-pyrrolidinone, 1-(4-[1-Pyrrolidinyl]2-butynyl)-2-pyrrolidinone
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所有图片(4)
About This Item
经验公式（希尔记法）:
C12H18N2O · 1.5C4H4O4 · xH2O
CAS号:
分子量:
380.39 (anhydrous basis)
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
检测方案
≥98% (HPLC)
形式
solid
mp
102-105 °C (lit.)
溶解性
H2O: >10 mg/mL
储存温度
2-8°C
SMILES字符串
[H]\C(=C(\[H])C(O)=O)C(O)=O.[H]\C(=C(\[H])C(O)=O)C(O)=O.[H]\C(=C(\[H])C(O)=O)C(O)=O.O=C1CCCN1CC#CCN2CCCC2.O=C3CCCN3CC#CCN4CCCC4
InChI
1S/2C12H18N2O.3C4H4O4/c2*15-12-6-5-11-14(12)10-4-3-9-13-7-1-2-8-13;3*5-3(6)1-2-4(7)8/h2*1-2,5-11H2;3*1-2H,(H,5,6)(H,7,8)/b;;3*2-1+
InChI key
WLYYOFJEBGHKEC-VQYXCCSOSA-N
基因信息
human ... CHRM2(1129)
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生化/生理作用
Oxotremorine sesquifumarate salt is a muscarinic acetylcholine receptor agonist with preference for the M2 receptor.
警示用语：
Danger
危险分类
Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
J D Brioni et al.
Behavioral and neural biology, 50(3), 251-254 (1988-11-01)
The pre-test administration of beta-endorphin (0.05 microgram/mouse), oxotremorine sesquifumarate (5.0 micrograms/mouse), or beta-endorphin plus oxotremorine enhanced retention test performance of a conditioned emotional response in mice. The effects were blocked by scopolamine. Scopolamine had no effect of its own. The
I B Introini-Collison et al.
Behavioral and neural biology, 57(3), 248-255 (1992-05-01)
Post-training administration of the centrally acting muscarinic agonist oxotremorine (50.0 microgram/kg, ip) facilitated 48-hr retention, in mice, of a one-trial step-through inhibitory avoidance response. Oxotremorine-induced memory facilitation was not prevented by the simultaneous post-training administration of the central beta-adrenoceptor antagonist
P G Gunasekar et al.
Neuroscience research, 49(1), 13-18 (2004-04-22)
Cyanide is generated in neurons and this report examines the two different receptors which mediate cyanide formation in neuronal tissue. An opiate receptor blocked by naloxone increases cyanide production both in rat brain and in rat pheochromocytoma (PC12) cells. A
T Reinheimer et al.
American journal of respiratory and critical care medicine, 156(2 Pt 1), 389-395 (1997-08-01)
Human bronchi were incubated in organ baths to measure histamine release. The calcium ionophore A23187 (10 mumol/L; 1 min) stimulated histamine release by 148 +/- 28% (n = 11) above the prestimulation level but was ineffective in epithelium-denuded bronchi. Neither
I Izquierdo et al.
Pharmacology, biochemistry, and behavior, 33(3), 545-548 (1989-07-01)
CD-1 mice were trained in a classically conditioned emotional response paradigm and tested 24 hr later. Exposure to an open field 0 or 1, but not 3 hr after training retroactively interfered with retention of the conditioned emotional response. The
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