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About This Item
经验公式（希尔记法）:
C18H20FN3O4
CAS号:
分子量:
361.37
MDL编号:
UNSPSC代码:
51282956
PubChem化学物质编号:
NACRES:
NA.76
推荐产品
生物来源
synthetic
质量水平
方案
≥99% (HPLC)
表单
powder
溶解性
1 M NaOH: soluble 50 mg/mL
抗生素抗菌谱
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
作用机制
DNA synthesis | interferes
enzyme | inhibits
储存温度
2-8°C
SMILES字符串
FC1=C(C3=[c]4[n](cc([c]([c]4=C1)=O)C(=O)O)C(CO3)C)N2CCN(CC2)C
InChI
1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)
InChI key
GSDSWSVVBLHKDQ-UHFFFAOYSA-N
基因信息
human ... CSNK2A1(1457) , KCNH1(3756)
rat ... Gabra1(29705)
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相关类别
一般描述
化学结构：氟喹诺酮
应用
氧氟沙星是一种合成的氟喹诺酮，具有广谱抗菌活性。 它是萘啶酸类似物。 在进行视网膜复位手术之前将其给予患者。
生化/生理作用
氧氟沙星抑制细菌DNA旋转酶和拓扑异构酶IV，后者促进DNA复制和细胞分裂。 氧氟沙星已显示可将LytA从非活性E型转化为活性C型。 它是抑制肺炎球菌细胞壁降解毒力因子的手性分子。
其他说明
保存于密闭容器内，置于干燥通风处。
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
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The Journal of biological chemistry, 280(20), 19948-19957 (2005-03-17)
The search for new drugs against Streptococcus pneumoniae (pneumococcus) is driven by the 1.5 million deaths it causes annually. Choline-binding proteins attach to the pneumococcal cell wall through domains that recognize choline moieties, and their involvement in pneumococcal virulence makes
O Cekiç et al.
The British journal of ophthalmology, 83(10), 1183-1185 (1999-09-30)
To assess the subretinal fluid (SRF) levels of ofloxacin following topical, oral or combined administration. 31 patients undergoing conventional retinal reattachment surgery were randomly assigned to three groups. Nine patients received topical ofloxacin, 11 patients received oral ofloxacin, and the
Andrea Von Groll et al.
Antimicrobial agents and chemotherapy, 53(10), 4498-4500 (2009-08-19)
This study evaluated cross-resistance of Mycobacterium tuberculosis strains to ofloxacin, moxifloxacin, and gatifloxacin and investigated the presence of mutations in gyrA and gyrB. Fluoroquinolone susceptibilities were determined for 41 M. tuberculosis strains by the proportion method on 7H11, and MICs
S Güniz Küçükgüzel et al.
European journal of medicinal chemistry, 42(7), 893-901 (2007-04-10)
Three novel series of 2',4'-difluoro-4-hydroxybiphenyl-3-carboxylic acid derivatives namely 4-substituted-1,2,4-triazoline-3-thiones (4a-g); 2-substituted-1,3,4-thiadiazoles (5a-g) and 2-substituted-1,3,4-oxadiazoles (6a-g) have been synthesized. Twenty-one of the newly synthesized compounds were tested against various bacteria, fungi, yeast species and virus. In addition, we have replaced the
O Gutiérrez et al.
Antimicrobial agents and chemotherapy, 51(12), 4329-4335 (2007-10-17)
All (236) Pseudomonas aeruginosa isolates resistant to imipenem and/or meropenem collected during a multicenter (127-hospital) study in Spain were analyzed. Carbapenem-resistant isolates were found to be more frequently resistant to all beta-lactams and non-beta-lactam antibiotics than carbapenem-susceptible isolates (P <
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