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检测方案
≥98% (TLC)
质量水平
形式
powder
颜色
pale yellow
溶解性
ethanol: 1.2 mg/mL
DMSO: 5 mg/mL
H2O: insoluble
储存温度
2-8°C
SMILES字符串
O=C1ON=C2C=Nc3ccccc3N12
InChI
1S/C9H5N3O2/c13-9-12-7-4-2-1-3-6(7)10-5-8(12)11-14-9/h1-5H
InChI key
LZMHWZHOZLVYDL-UHFFFAOYSA-N
基因信息
human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)
应用
1H-[1,2,4]恶二唑[4,3-a]喹喔啉-1-酮已被用作亲和选择质谱 (AS-MS) 化合物结合检测中的氧化剂 作为可溶性鸟苷酸环化酶 (sGC) 抑制剂用于抑制S-亚硝基-N-乙酰基-DL-青霉胺 (SNAP) 诱导的cGMP生产。
生化/生理作用
H-[1,2,4]恶二唑并[4,3-a]喹喔啉-1-酮（ODQ）能够非竞争性地抑制一氧化氮敏感性鸟苷酸环化酶的作用，并且可能导致血红素辅基发生不可逆氧化。 ODQ已被用于研究环磷酸鸟苷（cGMP）途径在一氧化氮（NO）信号转导中的作用。
一氧化氮敏感性鸟苷酸环化酶的选择性抑制剂。
注意
吸湿
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Serena Materazzi et al.
Microvascular research, 109, 38-44 (2016-11-08)
The role of endogenous H2S has been highlighted as a gaseous transmitter. The vascular smooth muscle inhibitory effects of H2S have been characterized in isolated aorta and mesenteric arteries in rats and mice. Our study was aimed at investigating the
Characterization of 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one as a heme-site inhibitor of nitric oxide-sensitive guanylyl cyclase.
Schrammel A
Molecular Pharmacology, 50(1), 1-5 (1996)
J Garthwaite et al.
Molecular pharmacology, 48(2), 184-188 (1995-08-01)
In brain and other tissues, nitric oxide (NO) operates as a diffusible second messenger that stimulates the soluble form of the guanylyl cylase enzyme and so elicits an accumulation of cGMP in target cells. Inhibitors of NO synthesis have been
Yayoi Shiokawa et al.
Planta medica, 85(13), 1080-1087 (2019-07-26)
Although Acanthopanax senticosus root extract (ASRE), a functional food used in Japan, improves peripheral blood circulation and exerts vasorelaxant effects in rats under healthy conditions, the underlying mechanisms currently remain unclear. Therefore, we investigated the mechanisms responsible for ASRE-induced relaxation
A Novel Selective Soluble Guanylate Cyclase Activator, MGV354, Lowers Intraocular Pressure in Preclinical Models, Following Topical Ocular Dosing
Prasanna G, et al.
Investigative Ophthalmology & Visual Science, 59(5), 1704-1716 (2018)
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