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关于此项目
经验公式(希尔记法):
C26H29N3O6 · HCl
化学文摘社编号:
分子量:
515.99
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
259-198-4
MDL number:
产品名称
尼卡地平 盐酸盐, powder, ≥98%
Quality Level
assay
≥98%
form
powder
color
yellow
solubility
DMSO: ~1 mg/mL, 0.1 M NaOH: insoluble, H2O: slightly soluble, methanol: soluble
originator
EKR Therapeutics
storage temp.
2-8°C
SMILES string
Cl[H].COC(=O)C1=C(C)NC(C)=C(C1c2cccc(c2)[N+]([O-])=O)C(=O)OCCN(C)Cc3ccccc3
InChI
1S/C26H29N3O6.ClH/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19;/h5-12,15,24,27H,13-14,16H2,1-4H3;1H
InChI key
AIKVCUNQWYTVTO-UHFFFAOYSA-N
Gene Information
human ... CACNA1C(775), CACNA1D(776), CACNA1F(778), CACNA1S(779)
Biochem/physiol Actions
阻断 L 型电压依赖性钙通道;抗高血压药。
Features and Benefits
该化合物由 EKR Therapeutics 开发 。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表, 点击这里 。
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signalword
Danger
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
hcodes
Hazard Classifications
Acute Tox. 3 Oral
T J Hibberd et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 29(10), 1-12 (2017-04-19)
Relatively little is known about the electrical rhythmicity of the whole colon, where long neural pathways are preserved. Smooth muscle electrical activity was recorded extracellularly from the serosa of isolated flat-sheet preparations consisting of the whole mouse colon (n=31). Two
GoEun Han et al.
Frontiers in neuroscience, 16, 969712-969712 (2022-11-08)
Non-rapid eye movement (NREM) sleep is tightly homeostatically regulated and essential for survival. In the electroencephalogram (EEG), oscillations in the delta (0.5-4 Hz) range are prominent during NREM sleep. These delta oscillations are, to date, the best indicator for homeostatic
S Thellung et al.
Neurobiology of disease, 7(4), 299-309 (2000-08-31)
Prion diseases are neurodegenerative pathologies characterized by the accumulation, in the brain, of altered forms of the prion protein (PrP), named PrP(Sc). A synthetic peptide homologous to residues 106-126 of PrP (PrP106-126) was reported to maintain the neurodegenerative characteristics of
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| N7510-5G | 04061832962283 |
| N7510-1G | 04061835506514 |
| N7510-10G | 04061832962276 |
