N7502
DL-缬氨酸
≥98% (HPLC), suitable for HPLC
别名:
(±)-2-氨基戊酸
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关于此项目
线性分子式:
CH3CH2CH2CH(NH2)COOH
化学文摘社编号:
分子量:
117.15
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
212-082-7
MDL number:
Beilstein/REAXYS Number:
1721163
产品名称
DL-缬氨酸,
InChI key
SNDPXSYFESPGGJ-UHFFFAOYSA-N
InChI
1S/C5H11NO2/c1-2-3-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)
SMILES string
CCCC(N)C(O)=O
assay
≥98% (HPLC)
form
powder
technique(s)
HPLC: suitable
color
white
mp
>300 °C
Quality Level
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Application
DL-正缬氨酸作为内部标准品，已用于：
- 气相色谱-质谱法(GC-MS)分析哺乳动物培养细胞的代谢物
- 将半胱氨酸和胱氨酸转化为Cys MPA(S-2-羧乙基硫代-L-半胱氨酸)，并采用高效液相色谱(HPLC)分析仪进行定量分析
- 液相色谱法分析卵母细胞样本中的游离氨基酸
Biochem/physiol Actions
DL-戊氨酸是一种神经递质。
正缬氨酸介导促进一氧化氮生成的生理和病理生理过程。可用于治疗阿尔茨海默病，并可有效抵抗大鼠模型的代谢综合征。正缬氨酸冷却到190K以下后会发生相变，因此可用于分子机器。DL-正缬氨酸可作为含线性侧链的脂肪族α-氨基酸的多态性和分子动力学研究的原型，影响蛋白质的活性、稳定性和侧链堆积。
General description
正缬氨酸(Norvaline)是一种非蛋白质α-氨基酸，又名DL-α-氨基戊酸。它产自大肠杆菌等革兰氏阴性菌，也是枯草芽孢杆菌所产抗真菌肽的组分。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Thekla Cordes et al.
Methods in molecular biology (Clifton, N.J.), 1978, 219-241 (2019-05-24)
Metabolism plays a central role in virtually all diseases, including diabetes, cancer, and neurodegeneration. Detailed analysis is required to identify the specific metabolic pathways dysregulated in the context of a given disease or biological perturbation. Measurement of metabolite concentrations can
Jens Neu et al.
Physical chemistry chemical physics : PCCP, 20(1), 276-283 (2017-12-06)
dl-Norvaline is a molecular crystal at room temperature and it undergoes a phase transition when cooled below 190 K. This phase transition is believed to be Martensitic, thus making it of particular interest for molecular machines. In this paper we
Sahar Mejri et al.
Fish physiology and biochemistry, 46(2), 699-712 (2019-12-19)
Bonefishes (Albula spp.) are classified within the superorder Elopomorpha, which is comprised of over 1000 species that share a unique leptocephalus larval stage. Bonefishes have a circum-tropical distribution, inhabiting inshore shallow water flats and gathering in presumptive nearshore pre-spawn aggregations
Esther W Lim et al.
Methods in molecular biology (Clifton, N.J.), 2088, 51-71 (2020-01-02)
Oxidation-reduction (redox) reactions are ubiquitous in biology and typically occur in specific subcellular compartments. In cells, the electron transfer between molecules and organelles is commonly facilitated by pyridine nucleotides such as nicotinamide adenine dinucleotide phosphate (NADPH) and nicotinamide adenine dinucleotide
Ramasamy Sankaranarayanan et al.
Journal of molecular biology, 375(4), 1052-1063 (2007-12-08)
Mycobacterium tuberculosis ornithine carbamoyltransferase (Mtb OTC) catalyzes the sixth step in arginine biosynthesis; it produces citrulline from carbamoyl phosphate (CP) and ornithine (ORN). Here, we report the crystal structures of Mtb OTC in orthorhombic (form I) and hexagonal (form II)
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