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Merck
CN

N5755

β-磷酸烟酰胺腺嘌呤二核苷酸 水合物

别名:

β-NADP, NADP, TPN, 三磷酸吡啶核苷酸, 辅酶 II

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关于此项目

经验公式（希尔记法）:
C21H28N7O17P3 · xH2O
化学文摘社编号:
53-59-8
分子量:
743.41 (anhydrous basis)
NACRES:
NA.51
PubChem Substance ID:
24897747
UNSPSC Code:
41106305
MDL number:
MFCD10567218

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InChI

1S/C21H28N7O17P3.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);1H2/t10-,11-,13-,14-,15-,16-,20-,21-;/m1./s1

SMILES string

O.NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(O)=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O

InChI key

ZKJOXOJMGXFSPF-QYZPTAICSA-N

biological source

chicken liver

assay

≥95% (HPLC)
≥95% (spectrophotometric assay)

form

powder

solubility

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

cation traces

sodium and potassium: ≤0.04%

storage temp.

−20°C

Quality Level

200

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相关类别

Application

β-烟酰胺腺嘌呤二核苷酸磷酸水合物适合用于：
  • 测量葡萄糖-6-磷酸脱氢酶活性
  • 在细胞色素P450 3A4检测中是NADPH-再生系统的一部分
  • 细胞色素P450 2D6分析中是NADPH再生系统的一部分
  • 测量葡萄糖-6-磷酸含量

Biochem/physiol Actions

β-烟酰胺腺嘌呤二核苷酸2′-磷酸（NADP+）和β-烟酰胺腺嘌呤二核苷酸2′-磷酸还原（NADPH）组成辅酶氧化还原对 (NADP+:NADPH) ，参与广泛的酶催化氧化还原反应。NADP+/NADPH氧还对在合成代谢反应，比如脂类和胆固醇生物合成以及脂肪酰链延伸中帮助电子传递。 NADP+/NADPH氧还对用于多种抗氧化机制，保护抵抗活性氧化簇积累。NADPH在体内是通过磷酸戊糖途径（PPP）产生的。
电子受体

Other Notes

根据固体质量包装。
这是NADP的常见形式。

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000511579
0000511580
0000511580
0000511579
0000498000

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T M Lilley et al.
Oecologia, 175(3), 811-823 (2014-05-20)
Harmful reactive oxygen species (ROS) produced during metabolism and immune responses are neutralized in part by a powerful enzymatic antioxidant system. Inter-species variability in the baseline activity of antioxidant enzymes may be explained by a variety of life history traits.
Raoul G Rosenthal et al.
Nature chemical biology, 10(1), 50-55 (2013-11-19)
The pyridine nucleotides NADH and NADPH (NAD(P)H) are ubiquitous redox coenzymes that are present in all living cells. Although about 16% of all characterized enzymes use pyridine nucleotides as hydride donors or acceptors during catalysis, a detailed understanding of how
Bent H Hellum et al.
Basic & clinical pharmacology & toxicology, 102(5), 466-475 (2008-03-12)
Extracts of six commonly used commercially available herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut were investigated for their in vitro inhibitory potential of CYP3A4 mediated metabolism and P-glycoprotein efflux transport activity.
Bent H Hellum et al.
Basic & clinical pharmacology & toxicology, 101(5), 350-358 (2007-10-04)
The six commonly used trade herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut, and ethanol, were investigated for their in vitro inhibitory potential of cytochrome P450 2D6 (CYP2D6)-mediated metabolism. Herbal components were
William B. Wood
Biochemistry: A Problems Approach, 195-195 null
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