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Merck
CN
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文件

N5755

Sigma-Aldrich

β-磷酸烟酰胺腺嘌呤二核苷酸 水合物

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别名:
β-NADP, NADP, TPN, 三磷酸吡啶核苷酸, 辅酶 II
经验公式（希尔记法）:
C21H28N7O17P3 · xH2O
CAS号:
53-59-8
分子量:
743.41 (anhydrous basis)
MDL编号:
MFCD10567218
UNSPSC代码:
41106305
PubChem化学物质编号:
24897747
NACRES:
NA.51

检测方案

≥95% (HPLC)
≥95% (spectrophotometric assay)

质量水平

200

形式

powder

溶解性

H2O: soluble 50 mg/mL, clear, colorless to faintly yellow

痕量阳离子

sodium and potassium: ≤0.04%

储存温度

−20°C

SMILES字符串

O.NC(=O)c1ccc[n+](c1)[C@@H]2O[C@H](COP([O-])(=O)OP(O)(=O)OC[C@H]3O[C@H]([C@H](OP(O)(O)=O)[C@@H]3O)n4cnc5c(N)ncnc45)[C@@H](O)[C@H]2O

InChI

1S/C21H28N7O17P3.H2O/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;/h1-4,7-8,10-11,13-16,20-21,29-31H,5-6H2,(H7-,22,23,24,25,32,33,34,35,36,37,38,39);1H2/t10-,11-,13-,14-,15-,16-,20-,21-;/m1./s1

InChI key

ZKJOXOJMGXFSPF-QYZPTAICSA-N

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相关类别

应用

β-烟酰胺腺嘌呤二核苷酸磷酸水合物适合用于：
  • 测量葡萄糖-6-磷酸脱氢酶活性
  • 在细胞色素P450 3A4检测中是NADPH-再生系统的一部分
  • 细胞色素P450 2D6分析中是NADPH再生系统的一部分
  • 测量葡萄糖-6-磷酸含量

生化/生理作用

β-烟酰胺腺嘌呤二核苷酸2′-磷酸（NADP+）和β-烟酰胺腺嘌呤二核苷酸2′-磷酸还原（NADPH）组成辅酶氧化还原对 (NADP+:NADPH) ，参与广泛的酶催化氧化还原反应。NADP+/NADPH氧还对在合成代谢反应，比如脂类和胆固醇生物合成以及脂肪酰链延伸中帮助电子传递。 NADP+/NADPH氧还对用于多种抗氧化机制，保护抵抗活性氧化簇积累。NADPH在体内是通过磷酸戊糖途径（PPP）产生的。
电子受体

其他说明

根据固体质量包装。
这是NADP的常见形式。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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