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N3398

Sigma-Aldrich

S-亚硝基-N-乙酰基-DL-青霉胺

≥97%, powder

别名:

N-乙酰基-3-(硫代亚硝基)-DL-缬氨酸, S-亚硝基-N-乙酰青霉胺, SNAP

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About This Item

经验公式（希尔记法）:
C7H12N2O4S
CAS号:
67776-06-1
分子量:
220.25
MDL编号:
MFCD00272624
UNSPSC代码:
12352116
PubChem化学物质编号:
24278584
NACRES:
NA.32

质量水平

300

方案

≥97%

表单

powder

颜色

faint green to very dark green

溶解性

H2O: ≥2 mg/mL
DMSO: ≥20 mg/mL, clear (faint green to very dark green)

储存温度

−20°C

SMILES字符串

CC(=O)NC(C(O)=O)C(C)(C)SN=O

InChI

1S/C7H12N2O4S/c1-4(10)8-5(6(11)12)7(2,3)14-9-13/h5H,1-3H3,(H,8,10)(H,11,12)

InChI key

ZIIQCSMRQKCOCT-UHFFFAOYSA-N

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应用

S-亚硝基-N-乙酰基-DL-青霉胺（SNAP）用于：
  • 作为亚硝酸盐生成实验中的阳性对照。
  • 阻断内源性转谷氨酰胺酶（TG2）的活性。
  • 细胞增殖实验，在细胞培养物中产生一氧化氮(NO)。

生化/生理作用

NO供体；血管扩张剂、平滑肌松弛剂、淋巴细胞激活剂。 激活可溶性鸟苷酸环化酶。
SNAP是一种亚硝基硫醇衍生物，在生理条件下释放一氧化氮（NO），从而使其成为研究NO的药理学和生理学作用的有用工具。由于SNAP具有释放NO的特性，所有其在体内和体外均是有效的血管扩张剂，不易产生药理学耐受性。

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H315,H319,H335

危险分类

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000374442
0000325076
0000192521
0000151288
0000192519

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Australian veterinary journal, 95(12), 462-468 (2017-12-16)
To determine the prevalence of selected canine vector-borne diseases (Leishmania infantum, Anaplasma spp., Ehrlichia canis, Borrelia burgdorferi and Dirofilaria immitis) and endo- and ectoparasites in Samoan dogs presenting for surgical sterilisation and to report on the general health management of
The redox state of transglutaminase 2 controls arterial remodeling.
van den Akker J
PLoS ONE, 6(8), e23067-e23067 (2011)
Shambhuprasad K Togarsimalemath et al.
Kidney international, 92(4), 876-887 (2017-07-22)
The intrinsic similarity shared between the members of the complement factor H family, which comprises complement factor H and five complement factor H-related (CFHR) genes, leads to various recombination events. In turn these events lead to deletions of some genes
Zorana Milanović et al.
Journal of veterinary internal medicine, 33(4), 1686-1694 (2019-06-09)
Babesia canis infection induces a marked acute phase response (APR) that might be associated with alteration in lipid and lipoprotein metabolism and disease prognosis. Dogs with B. canis-induced APR develop dyslipidemia with altered lipoprotein concentration and morphology. Twenty-nine client-owned dogs
Akshata R Naik et al.
The journal of physical chemistry. B, 123(32), 6997-7005 (2019-07-20)
The cell plasma membrane is a highly dynamic organelle governing a wide range of cellular activities including ion transport, secretion, cell division, growth, and development. The fundamental process involved in the addition of new membranes to pre-existing plasma membranes, however
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