推荐产品
生物来源
rabbit
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
种属反应性
human, mouse, bovine
技术
immunohistochemistry (frozen sections): 1:100 using acetone-fixed, frozen tissue sections of mouse heart
microarray: suitable
western blot: 1:10,000 using bovine lung endothelial cell extract
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... NOS3(4846)
mouse ... Nos3(18127)
一般描述
The gene encoding endothelial nitric oxide synthase (eNOS) is localized on human chromosome 7q35-36 and has 26 exons.
eNOS encodes a 135 kDa protein and is localized in endothelial cells. Human bNOS and eNOS share 52% amino acid identity, and rat and human bNOS share 93% amino acid identity. eNOS is not restricted to the endothelium of blood vessels but exists in the epithelium of several tissues.
免疫原
synthetic peptide corresponding to nitric oxide synthase (NOS) of bovine endothelial origin (eNOS, amino acids 596-609) conjugated to KLH. The immunogen sequence is identical in human eNOS.
应用
Anti-Nitric Oxide Synthase, Endothelial (596-609) antibody produced in rabbit has been used in western blotting.
生化/生理作用
Endothelial nitric oxide synthase (eNOS) is a modulator of vascular function and it is involved in the production of nitric oxide. Defects in the enzyme expression have been shown to be associated coronary artery disease.
Endothelial nitric oxide synthase (eNOS) is constitutively expressed and are dependent on Ca2+/ calmodulin for nitricoxide (NO) production.
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298
Tesauro M, et al.
Proceedings of the National Academy of Sciences of the USA, 97(6), 2832-2835 (2000)
Nitric oxide production by mouse renal tubules can be increased by a sodium-dependent mechanism
Kempson S, et al.
Nitric Oxide, 17(1), 33-43 (2007)
Vascular nitric oxide: Beyond eNOS
Zhao Y, et al.
Journal of Pharmacological Sciences, 129(2), 83-94 (2015)
Ang-(1-7) protects HUVECs from high glucose-induced injury and inflammation via inhibition of the JAK2/STAT3 pathway
Chen J, et al.
International Journal of Molecular Medicine, 41(5), 2865-2878 (2018)
Molecular basis of cell-specific endothelial nitric-oxide synthase expression in airway epithelium
German Z, et al.
The Journal of Biological Chemistry, 275(11), 8183-8189 (2000)
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