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Merck
CN

N2255

Sigma-Aldrich

S-(4-硝基苄基)-6-硫肌苷

≥98%, solid

别名:

6-[(4-硝基苄基)硫代]-9-β-D-呋喃核糖基嘌呤, NBMPR, NBTI

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About This Item

经验公式(希尔记法):
C17H17N5O6S
CAS号:
分子量:
419.41
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98%

表单

solid

颜色

white

mp

187-190 °C (lit.)

溶解性

0.1 M HCl: slightly soluble
0.1 M NaOH: slightly soluble
DMSO: soluble
H2O: insoluble

储存温度

2-8°C

SMILES字符串

OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(SCc4ccc(cc4)[N+]([O-])=O)ncnc23

InChI

1S/C17H17N5O6S/c23-5-11-13(24)14(25)17(28-11)21-8-20-12-15(21)18-7-19-16(12)29-6-9-1-3-10(4-2-9)22(26)27/h1-4,7-8,11,13-14,17,23-25H,5-6H2/t11-,13-,14-,17-/m1/s1

InChI key

DYCJFJRCWPVDHY-LSCFUAHRSA-N

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一般描述

S-(4-硝基苄基)-6-硫代肌苷(NBTI)属于S6取代的6-硫代嘌呤核苷家族,可调节动物体内的核苷转运机制。它能作为腺苷转运蛋白的一种配体。NBTI的结合位点位于脑毛细血管上。它可作为共价光亲和探针用于核苷转运。

生化/生理作用

中枢神经系统和血管平滑肌中平衡核苷转运蛋白(ENT),尤其是腺苷转运蛋白的抑制剂。
有效的腺苷摄取抑制剂

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)


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分析证书(COA)

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